SB 297006,CCR3拮抗剂(ab120821)
Key features and details
- Potent, selective CCR3 antagonist
- CAS Number: 58816-69-6
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
SB 297006,CCR3拮抗剂 -
描述
Potent,selective CCR3拮抗剂 -
生物学描述
Highly potent, selective CCR3 antagonist (IC50 = 2.5 μM). Displays 250-fold selectivity for CCR3 vs. CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC50 values are 210, 90 and 80 nM, respectively).
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纯度
> 99% -
CAS编号
58816-69-6 -
化学结构
性能
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化学名称
N-Benzoyl-4-nitro-L-phenylalanine ethyl ester -
分子量
342.35 -
分子式
C18H18N2O5 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120821 被引用在 1 文献中.
- Kuse Y et al. CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure. Front Pharmacol 8:207 (2017). PubMed: 28458639