Key features and details
- Rabbit polyclonal to Retinoic Acid Receptor beta
- Suitable for: WB
- Reacts with: Mouse, Human, Saccharomyces cerevisiae
- Isotype: IgG
产品名称Anti-Retinoic Acid Receptor beta抗体
参阅全部 Retinoic Acid Receptor beta 一抗
描述兔多克隆抗体to Retinoic Acid Receptor beta
特异性This antibody shows slight cross-reactivity to RAR alpha but does not detect RAR gamma.
经测试应用适用于: WBmore details
种属反应性与反应: Mouse, Human, Saccharomyces cerevisiae
- SH-SY5Y cell extract.
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.05% Sodium azide
Constituent: 99% PBS
Concentration information loading...
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
Our Abpromise guarantee covers the use of ab5792 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Detects a band of approximately 52 kDa (predicted molecular weight: 53 kDa).|
功能Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
疾病相关Microphthalmia, syndromic, 12
序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
细胞定位Cytoplasm and Nucleus.
- Information by UniProt
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All lanes : Anti-Retinoic Acid Receptor beta antibody (ab5792) at 1/1000 dilution
Lane 1 : SH-SY5Y cell lysate
Lane 2 : HepG2 cell lysate
Lane 3 : Mouse heart cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 53 kDa
Observed band size: 58 kDa why is the actual band size different from the predicted?