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Epigenetics and Nuclear Signaling Transcription Domain Families Zinc Finger

Retinoic Acid Receptor alpha多肽(ab4910)

  • Datasheet
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Key features and details

  • Purity: > 95% SDS-PAGE
  • Suitable for: Blocking

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描述

  • 产品名称

    Retinoic Acid Receptor alpha多肽
    参阅全部 Retinoic Acid Receptor alpha 蛋白酶
  • 纯度

    > 95 % SDS-PAGE.

  • 无动物成分

    No
  • 性质

    Synthetic

技术指标

Our Abpromise guarantee covers the use of ab4910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式

    Liquid
  • 补充说明


    This peptide may be used for control experiments with the monoclonal and polyclonal antibodies that react with this product and the RAR catalogue ab5791 and ab5423. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名

    • NR1B1
    • Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein
    • Nuclear receptor subfamily 1 group B member 1
    • Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form
    • RAR
    • RAR alpha
    • RAR-alpha
    • rara
    • RARA_HUMAN
    • RARalpha
    • RARalpha1
    • Retinoic acid nuclear receptor alpha variant 1
    • Retinoic acid nuclear receptor alpha variant 2
    • Retinoic acid receptor alpha
    • Retinoic acid receptor alpha polypeptide
    see all
  • 功能

    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing MLL5. Mediates retinoic acid-induced granulopoiesis.
  • 疾病相关

    Note=Chromosomal aberrations involving RARA are commonly found in acute promyelocytic leukemia. Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM. The PML-RARA oncoprotein requires both the PML ring structure and coiled-coil domain for both interaction with UBE2I, nuclear microspeckle location and sumoylation. In addition, the coiled-coil domain functions in blocking RA-mediated transactivation and cell differentiation.
  • 序列相似性

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 翻译后修饰

    Phosphorylated on serine and threonine residues. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity (By similarity). Phosphorylation by AKT1 is required for the repressor activity but has no effect on DNA binding, protein stability nor subcellular localization. Phosporylated by PKA in vitro. This phosphorylation on Ser-219 and Ser-369 is critical for ligand binding, nuclear localization and transcriptional activity in response to FSH signaling.
    Sumoylated by SUMO2, mainly on Lys-399 which is also required for SENP6 binding. On all-trans retinoic acid (ATRA) binding, a confromational change may occur that allows sumoylation on two additional site, Lys-166 and Lys-171. Probably desumoylated by SENP6. Sumoylation levels determine nuclear localization and regulate ATRA-mediated transcriptional activity.
    Trimethylation enhances heterodimerization with RXRA and positively modulates the transcriptional activation.
    Ubiquitinated.
  • 细胞定位

    Nucleus. Cytoplasm. Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.
  • Target information above from: UniProt accession P10276 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

实验方案

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

数据表及文件

  • Datasheet download

    Download

文献 (0)

发表研究结果有使用 ab4910?请让我们知道,以便我们可以引用本数据表中的参考文章。

ab4910 尚未被引用在任何文献中。

客户评价及客户问答

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Question

Dear Tech:

I have bought a vial of ab4910. I would like to know whether the storage buffer conrtains Tris-base or not,could you provide us with this information?

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Abcam community

Verified customer

Asked on Dec 05 2012

Answer

Thank you for your enquiry.

There is no Tris-base in the storage buffer. The peptide was dissolved in distilled water.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Abcam Scientific Support

回复于 Dec 05 2012

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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