概述

描述

  • 性质
    Recombinant
  • 来源
    Mammalian
  • 氨基酸序列
    • Accession
    • 种属
      Mouse
    • 序列
      FYDTETLKVIDEEWQRTQCSPRETCVEVASELGKTTNTFFKPPCVNVFRC GGCCNEEGVMCMNTS TSYISKQLFEISVPLTSVPELVPVKIANHTGCKCLPTGPRHPYSVDHHHH HH
    • 分子量
      13 kDa including tags
    • 氨基酸
      98 to 206
    • 标签
      His tag C-Terminus

技术指标

Our Abpromise guarantee covers the use of ab185847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    HPLC

    SDS-PAGE

  • 内毒素水平
    < 1.000 Eu/µg
  • 纯度
    >95% by SDS-PAGE .
    Assessed also by SEC-HPLC
  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at Room Temperature. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: 100% PBS

    Lyophilized from a 0.2 µM filtered solution

  • 复溶
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 3X PBS.

常规信息

  • 别名
    • c-fos induced growth factor
    • c-fos induced growth factor (vascular endothelial growth factor D)
    • c-fos-induced growth factor
    • FIGF
    • Vascular endothelial growth factor D
    • Vascular endothelial growth factor D precursor
    • VEGF D
    • VEGF-D
    • VEGFD
    • VEGFD_HUMAN
    see all
  • 功能
    Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
  • 组织特异性
    Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
  • 序列相似性
    Belongs to the PDGF/VEGF growth factor family.
  • 翻译后修饰
    Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • 细胞定位
    Secreted.
  • Information by UniProt

文献

ab185847 has not yet been referenced specifically in any publications.

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