参阅全部 TPA Tissue Plasminogen Activator 蛋白酶
蛋白长度Full length protein
- Anti-TPA Tissue Plasminogen Activator antibody (ab14198)
- Anti-TPA Tissue Plasminogen Activator antibody [2A153] (ab21049)
- Anti-TPA Tissue Plasminogen Activator antibody [629.2A1.53] (ab27418)
- Anti-TPA Tissue Plasminogen Activator antibody (ab28219)
- Anti-TPA Tissue Plasminogen Activator antibody (FITC) (ab28376)
- Anti-TPA Tissue Plasminogen Activator antibody (ab47033)
- Anti-TPA Tissue Plasminogen Activator antibody (ab48649)
- Anti-TPA Tissue Plasminogen Activator antibody (Biotin) (ab51518)
Our Abpromise guarantee covers the use of ab92633 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性Specific activity: 593,600 IU/mg (Relative to WHO International Standard for Human Recombinant Tissue Plasminogen Activator, NIBSC 98/714).
纯度> 95 % SDS-PAGE.
ab92633 is > 98% pure by SDS-PAGE.
Concentration information loading...
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 9.52% HEPES, 0.58% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Plasminogen activator tissue
功能Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration.
组织特异性Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
疾病相关Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
序列相似性Belongs to the peptidase S1 family.
Contains 1 EGF-like domain.
Contains 1 fibronectin type-I domain.
Contains 2 kringle domains.
Contains 1 peptidase S1 domain.
结构域Both FN1 and one of the kringle domains are required for binding to fibrin.
Both FN1 and EGF-like domains are important for binding to LRP1.
The FN1 domain mediates binding to annexin A2.
The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site.
翻译后修饰The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.
Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.
N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.
Characterization of O-linked glycan was studied in Bowes melanoma cell line.
细胞定位Secreted > extracellular space.
- Information by UniProt
ab92633 has not yet been referenced specifically in any publications.