重组人TGF beta 3蛋白(Animal Free) (ab217402)
Key features and details
- Expression system: Escherichia coli
- Purity: > 98% SDS-PAGE
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE, HPLC
描述
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产品名称
重组人TGF beta 3蛋白(Animal Free)
参阅全部 TGF beta 3 蛋白酶 -
生物活性
Determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/mL, corresponding to a specific activity of ≥ 2 x 107 units/mg.
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纯度
> 98 % SDS-PAGE.
> 98 % HPLC. -
表达系统
Escherichia coli -
Accession
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蛋白长度
Full length protein -
无动物成分
Yes -
性质
Recombinant -
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种属
Human -
序列
ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPY LRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQ LSNMVVKSCKCS -
预测分子量
25 kDa -
氨基酸
301 to 412 -
额外的序列信息
Recombinant Human TGF-β3 is composed of two identical 12.7 kDa, 112 amino acid polypeptide chains linked by a single disulfide bond.
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技术指标
Our Abpromise guarantee covers the use of ab217402 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Functional Studies
SDS-PAGE
HPLC
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形式
Lyophilized -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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复溶For lot specific reconstitution information please contact our Scientific Support Team.
常规信息
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别名
- ARVD
- ARVD1
- FLJ16571
see all -
功能
Involved in embryogenesis and cell differentiation. -
疾病相关
Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) [MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. -
序列相似性
Belongs to the TGF-beta family. -
细胞定位
Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (2)
ab217402 被引用在 2 文献中.
- Finger AM et al. Intercellular coupling between peripheral circadian oscillators by TGF-ß signaling. Sci Adv 7:N/A (2021). PubMed: 34301601
- Gan D et al. Biphasic Effect of Pirfenidone on Angiogenesis. Front Pharmacol 12:804327 (2021). PubMed: 35069215