重组人PRKAR1A蛋白(ab125532)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 85% Densitometry
- Suitable for: WB, SDS-PAGE
描述
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产品名称
重组人PRKAR1A蛋白 -
纯度
> 85 % Densitometry.
Purity determined to be >85% by densitometry. Affinity purified. -
表达系统
Baculovirus infected Sf9 cells -
Accession
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蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
预测分子量
51 kDa including tags -
氨基酸
1 to 381
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab125532 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Western blot
SDS-PAGE
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形式
Liquid -
补充说明
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.00
Preservative: 1.02% Imidazole
Constituents: 0.002% PMSF, 0.82% Sodium phosphate, 0.0038% DTT, 25% Glycerol (glycerin, glycerine), 1.75% Sodium chloride
常规信息
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别名
- ACRDYS1
- ADOHR
- cAMP dependent protein kinase regulatory subunit alpha 1
see all -
组织特异性
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. -
疾病相关
Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
Defects in PRKAR1A are the cause of intracardiac myxoma (INTMYX) [MIM:255960]. Inheritance is autosomal recessive.
Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1) [MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can also be observed in patients without other manifestations or familial history. -
序列相似性
Belongs to the cAMP-dependent kinase regulatory chain family.
Contains 2 cyclic nucleotide-binding domains. -
翻译后修饰
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab125532 尚未被引用在任何文献中。