概述

  • 产品名称
    重组人PPAP2A蛋白
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • 种属
      Human
    • 序列
      MFDKTRLPYVALDVLCVLLAGLPFAILTSRHTPFQRGVFCNDESIKYPYK EDTIPYALLGGIIIPFSIIVIILGETLSVYCNLLHSNSFIRNNYIATIYK AIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIEY YICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRP TLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYVSDFF KERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP
    • 氨基酸
      1 to 284
    • 标签
      proprietary tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab160110 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Lipid phosphate phosphohydrolase 1
    • Lipid phosphate phosphohydrolase 1a
    • LLP1a
    • LPP1
    • LPP1_HUMAN
    • PAP 2a
    • PAP-2a
    • PAP2
    • PAP2-alpha
    • PAP2a
    • PAP2a2
    • PAP2alpha2
    • PAPalpha1
    • Phosphatidate phosphohydrolase type 2a
    • Phosphatidic acid phosphatase 2a
    • Phosphatidic acid phosphatase type 2A
    • Phosphatidic acid phosphohydrolase type 2a
    • PPAP2A
    • Type 2 phosphatidic acid phosphatase alpha
    • Type 2 phosphatidic acid phosphohydrolase
    see all
  • 功能
    Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
  • 组织特异性
    Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.
  • 序列相似性
    Belongs to the PA-phosphatase related phosphoesterase family.
  • 翻译后修饰
    N-glycosylated. Contains high-mannose oligosaccharides.
  • 细胞定位
    Cell membrane.
  • Information by UniProt

图片

  • ab160110 on a 12.5% SDS-PAGE stained with Coomassie Blue.

文献

ab160110 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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