概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • 种属
      Human
    • 序列
      GQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTM RMLSSTPPTPIACAPSAVNQAAPHQQNRIWEREPAPLLSAQYETLSDSDD
    • 氨基酸
      2341 to 2440
    • 标签
      proprietary tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab153002 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • hN CoR
    • hNCoR
    • KIAA1047
    • N CoR
    • N Cor/SMRT corepressor Rip13
    • N CoR1
    • N-CoR
    • N-CoR1
    • NCoR
    • NCOR 1
    • Ncor1
    • NCOR1_HUMAN
    • Nuclear receptor co repressor 1
    • Nuclear receptor corepressor 1
    • Retinoid X receptor interacting protein 13
    • RIP13
    • Rxrip13
    • thyroid hormone and retinoic acid receptor associated corepressor 1
    • TRAC 1
    • TRAC1
    see all
  • 功能
    Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
  • 序列相似性
    Belongs to the N-CoR nuclear receptor corepressors family.
    Contains 2 SANT domains.
  • 结构域
    The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
    The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.
  • 翻译后修饰
    Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
  • 细胞定位
    Nucleus.
  • Information by UniProt

图片

  • ab153002 on a 12.5% SDS-PAGE stained with Coomassie Blue.

文献

ab153002 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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