重组人Noxa蛋白(ab152618)
Key features and details
- Expression system: Wheat germ
- Suitable for: SDS-PAGE, WB, ELISA
描述
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产品名称
重组人Noxa蛋白 -
表达系统
Wheat germ -
蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
MPGKKARKNAQPSPARAPAGPAGTAGTARDQAGFAIGMQLRFTRGKKLLS SSLSSSPLALPRGHEEQVQVAGSRVCYSTQEIWRQTELPAETSESDIQTL LLRNLTASKTCMRGLLQKSFLRRCTFHQFEERLHCN -
预测分子量
41 kDa including tags -
氨基酸
1 to 136
-
技术指标
Our Abpromise guarantee covers the use of ab152618 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Western blot
ELISA
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形式
Liquid -
补充说明
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
常规信息
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别名
- Adult T cell leukemia derived PMA responsive
- APR
- APR_HUMAN
see all -
功能
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. -
组织特异性
Highly expressed in adult T-cell leukemia cell line. -
序列相似性
Belongs to the PMAIP1 family. -
结构域
The BH3 motif is essential for pro-apoptotic activity. -
细胞定位
Mitochondrion. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab152618 尚未被引用在任何文献中。