Induced myeloid leukemia cell differentiation protein Mcl 1
Induced myeloid leukemia cell differentiation protein Mcl-1
Myeloid Cell Leukemia 1
Myeloid cell leukemia ES
Myeloid cell leukemia sequence 1
Myeloid cell leukemia sequence 1 BCL2 related
Myeloid cell leukemia sequence 1 isoform 1
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Belongs to the Bcl-2 family.
Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
Membrane. Cytoplasm. Mitochondrion. Nucleus > nucleoplasm. Cytoplasmic, associated with mitochondria.
Chu R et al. Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified. Oncotarget7:78958-78970 (2016).
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