产品名称重组人ITK / EMT蛋白
参阅全部 ITK / EMT 蛋白酶
来源Baculovirus infected Sf9 cells
氨基酸352 to 620
Our Abpromise guarantee covers the use of ab79617 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性Specific Activity: 58 nmol/min/mg
纯度> 90 % SDS-PAGE.
Previously labelled as ITK.
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Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 0.0038% EGTA, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Homolog of mouse T cell itk/tsk
- IL 2 inducible T cell kinase
功能Plays a role in T-cell proliferation and differentiation.
组织特异性T-cell lines and natural killer cell lines.
疾病相关Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1) [MIM:613011]. LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma.
序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Contains 1 Btk-type zinc finger.
Contains 1 PH domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.
细胞定位Cell membrane. Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T-cells.
- Information by UniProt
ab79617 has not yet been referenced specifically in any publications.