概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • 种属
      Human
    • 序列
      RCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLI SRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEK
    • 氨基酸
      29 to 119
    • 标签
      proprietary tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab158704 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 17 @beta HSD III
    • 17 beta HSD 3
    • 17-@beta hydroxysteroid dehydrogenase III
    • 17-beta-HSD 3
    • 17-beta-hydroxysteroid dehydrogenase type 3
    • DHB3_HUMAN
    • EC 1.1.1.64
    • EDH17B3
    • Estradiol 17 beta dehydrogenase
    • Estradiol 17 beta dehydrogenase 3
    • HSD17B3
    • Hydroxysteroid (17 beta) dehydrogenase 3
    • OTTHUMP00000021718
    • SDR12C2
    • Short chain dehydrogenase/reductase family 12C member 2
    • Testicular 17 @beta hydroxysteroid dehydrogenase III
    • Testicular 17 beta hydroxysteroid dehydrogenase
    • Testicular 17-beta-hydroxysteroid dehydrogenase
    • Testosterone 17 beta dehydrogenase 3
    • Testosterone 17-beta-dehydrogenase 3
    see all
  • 功能
    Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.
  • 组织特异性
    Testis.
  • 通路
    Hormone biosynthesis; testosterone biosynthesis.
  • 疾病相关
    Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH) [MIM:264300]. These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place.
  • 序列相似性
    Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
  • Information by UniProt

图片

  • ab158704 on a 12.5% SDS-PAGE stained with Coomassie Blue.

文献

ab158704 has not yet been referenced specifically in any publications.

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