概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMSAPRESPLPYHIPLDPEGSLELSWNVSYT QEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSD QKGQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHL VYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQA PNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQ CAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLA FGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGIMELG LVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGR KVVTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTY NTEDRELATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHL INRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYSFAPISMHCNKS SAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQGRSPAGPTVVSIGGGKG
    • 分子量
      67 kDa including tags
    • 氨基酸
      40 to 617
    • 标签
      His tag N-Terminus
    • 额外的序列信息
      NP_000778. Soluble Dopamine beta Hydroxylase.

技术指标

Our Abpromise guarantee covers the use of ab202616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 85 % SDS-PAGE.
    ab202616 was purified by using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 89% PBS, 10% Glycerol, 0.02% DTT

常规信息

  • 别名
    • dbh
    • DBM
    • Dopamine beta hydroxylase
    • Dopamine beta monooxygenase
    • Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
    • Dopamine beta-monooxygenase
    • DOPO_HUMAN
    • OTTHUMP00000022501
    • Soluble dopamine beta-hydroxylase
    see all
  • 功能
    Conversion of dopamine to noradrenaline.
  • 通路
    Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
  • 疾病相关
    Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
  • 序列相似性
    Belongs to the copper type II ascorbate-dependent monooxygenase family.
    Contains 1 DOMON domain.
  • 细胞定位
    Cytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of ab202616 (3 µg).

文献

ab202616 has not yet been referenced specifically in any publications.

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