重组人Dkk3 (mutated R335G)蛋白(ab155717)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 1.000 Eu/µg
- Tags: His tag C-Terminus
- Suitable for: SDS-PAGE
描述
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产品名称
重组人Dkk3 (mutated R335G)蛋白
参阅全部 Dkk3 蛋白酶 -
纯度
> 95 % SDS-PAGE. -
内毒素水平
< 1.000 Eu/µg -
表达系统
HEK 293 cells -
Accession
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蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
APAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMEDTQHKLRSAVEE MEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNN QTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPC RGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCA FQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGL LCQPHSHSLVYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQEL EDLERSLTEEMALGEPAAAAAALLGGEEI -
预测分子量
37 kDa including tags -
分子量信息
The protein migrates as 45-65 kDa under reducing. -
氨基酸
22 to 350 -
修饰
mutated R335G -
标签
His tag C-Terminus
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab155717 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Lyophilized -
补充说明
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.40
Constituents: 95% PBS, 5% Trehalose -
复溶Reconstitute with sterile deionized water to a concentration of 400 µg/ml.
常规信息
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别名
- Dickkopf 3
- Dickkopf 3 homolog
- Dickkopf 3 homolog (Xenopus laevis)
see all -
功能
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. -
组织特异性
Highest expression in heart, brain, and spinal cord. -
序列相似性
Belongs to the dickkopf family. -
结构域
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6. -
翻译后修饰
N- and O-glycosylated. -
细胞定位
Secreted. - Information by UniProt
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab155717 尚未被引用在任何文献中。