This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cell division protein kinase 6
Cyclin dependent kinase 6
D3 type cyclin
G1 S specific cyclin D3
G1/S specific cyclin D3
Serine/threonine protein kinase PLSTIRE
CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of Cdk6 first appears in mid-G1 phase, and is controlled by regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
Cyclin D3 is a G1 cyclin closely related to cyclin D1 and D2. Cyclins D1, D2, and D3 are members of a growing superfamily of cyclins, proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of cyclin-dependent kinases (cdks). All three known members of the D-type subfamily form active kinase complexes in vivo with a distinct subset of cdks, particularly with cdk4 and cdk6.
CCND3: Cytoplasm. Nucleus
SDS-PAGE - Recombinant human CDK6 + CCND3 protein (ab84557)
SDS-PAGE of ab84557. CDK6 approximate MW 40kDa and CCND3 approximate MW 35kDa.
Functional Studies - Recombinant human CDK6 + CCND3 protein (ab84557)
Kinase Assay: Specific activity of CDK6/CCND3 was determined to be 36 nmol/min/mg using protein substrate Rb.
This product has been referenced in:
Wang Y et al. Design, synthesis and biological evaluation of pyrimidine derivatives as novel CDK2 inhibitors that induce apoptosis and cell cycle arrest in breast cancer cells. Bioorg Med Chem26:3491-3501 (2018).
Read more (PubMed: 29853338) »