重组人ADAMTSL3蛋白(ab127140)
Key features and details
- Expression system: Escherichia coli
- Purity: > 80% SDS-PAGE
- Tags: His-DHFR tag N-Terminus
- Suitable for: SDS-PAGE
描述
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产品名称
重组人ADAMTSL3蛋白 -
纯度
> 80 % SDS-PAGE.
Purified via His tag -
表达系统
Escherichia coli -
Accession
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蛋白长度
Protein fragment -
无动物成分
No -
性质
Recombinant -
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种属
Human -
预测分子量
29 kDa -
氨基酸
529 to 788 -
标签
His-DHFR tag N-Terminus
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab127140 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Lyophilized -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at -20ºC.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride
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复溶Reconstitute with water to desired concentration.
常规信息
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别名
- A disintegrin like and metalloprotease domain with thrombospondin type I motifs like 3
- ADAMTS like 3
- ADAMTS-like protein 3
see all -
组织特异性
Expressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate, epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon. -
序列相似性
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 PLAC domain.
Contains 10 TSP type-1 domains. -
翻译后修饰
Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. -
细胞定位
Secreted, extracellular space, extracellular matrix. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab127140 尚未被引用在任何文献中。