Key features and details
- Goat polyclonal to Rab11A
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
参阅全部 Rab11A 一抗
经测试应用适用于: WBmore details
- Mouse Heart lysate
常规说明Principal Names – RAB11A; YL8; RAB11A, member RAS oncogene family; RAB 11A, member oncogene family Official Gene Symbol - RAB11A GenBank Accession Number – NP_004654 LocusLink ID - 55072 (human) Gene Ontology terms - RAB small monomeric GTPase
存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium azide
Constituents: 0.5% Tris, 0.5% BSA
Concentration information loading...
纯度Immunogen affinity purified
纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Our Abpromise guarantee covers the use of ab2921 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 25-28 kDa (predicted molecular weight: 25 kDa).
A 1 hour primary incubation is recommended for this product. Approx 25-28kDa band seen in Mouse Heart lysate.
功能Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
序列相似性Belongs to the small GTPase superfamily. Rab family.
细胞定位Cell membrane. Recycling endosome membrane. Cleavage furrow. Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
- Information by UniProt
- MGC1490 antibody
- Rab 11 antibody
- Rab 11A antibody
ab2921 被引用在 1 文献中.
- Wrenn SM et al. Avian lungs: A novel scaffold for lung bioengineering. PLoS One 13:e0198956 (2018). PubMed: 29949597