Anti-PTP4A3/PRL-R抗体(ab50276)
Key features and details
- Rabbit polyclonal to PTP4A3/PRL-R
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PTP4A3/PRL-R抗体
参阅全部 PTP4A3/PRL-R 一抗 -
描述
兔多克隆抗体to PTP4A3/PRL-R -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide corresponding to Human PTP4A3/PRL-R aa 150-250 conjugated to keyhole limpet haemocyanin (Cysteine residue).
Database link: O75365 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: 0.0268% PBS -
Concentration information loading...
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纯度
IgG fraction -
纯化说明
Whole antiserum is fractionated and then further purified by ion-exchange chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab50276于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/250 - 1/500.
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WB |
1/500 - 1/1000. Predicted molecular weight: 25 kDa.
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说明 |
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IHC-P
1/250 - 1/500. |
WB
1/500 - 1/1000. Predicted molecular weight: 25 kDa. |
靶标
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功能
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. -
组织特异性
Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. -
序列相似性
Belongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain. -
翻译后修饰
Farnesylated. Farnesylation is required for membrane targeting. -
细胞定位
Cell membrane. Early endosome. - Information by UniProt
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数据库链接
- Entrez Gene: 11156 Human
- Entrez Gene: 19245 Mouse
- Omim: 606449 Human
- SwissProt: O75365 Human
- SwissProt: Q9D658 Mouse
- Unigene: 43666 Human
- Unigene: 744870 Human
- Unigene: 390807 Mouse
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别名
- Potentially prenylated protein tyrosine phosphatase antibody
- PRL 3 antibody
- PRL R antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (12)
ab50276 被引用在 12 文献中.
- Zhou Q et al. PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK. Theranostics 10:10345-10359 (2020). PubMed: 32929353
- Edwards DR et al. PRL-3 increases the aggressive phenotype of prostate cancer cells in vitro and its expression correlates with high-grade prostate tumors in patients. Int J Oncol 52:402-412 (2018). PubMed: 29207031
- Zhang Y et al. PRL-3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway in vitro and in vivo. Oncol Lett 15:9069-9074 (2018). PubMed: 29805638
- Xie H & Wang H PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression. Oncol Lett 15:2795-2800 (2018). PubMed: 29435006
- Li BH et al. Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway. Med Sci Monit 24:8105-8114 (2018). PubMed: 30418964