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Bielschowsky's silver stain is a very useful tool to detect nerve fibers. It can be used to stain axons, neurofibrils and senile plaques in the central nervous system. This method is easy to perform and is routinely used in the study of Alzheimer's disease together with antibody staining.
Fig 1. Example of axonal silver staining
Showing axons stained using Bielshchowsky's silver stain. 8 µm thick paraformaldehyde paraffin embedded of mouse cerebellum sections.