重组S. cerevisiae GRX2蛋白(ab63232)
Key features and details
- Expression system: Saccharomyces cerevisiae
- Purity: > 90% SDS-PAGE
- Suitable for: Functional Studies
描述
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产品名称
重组S. cerevisiae GRX2蛋白
参阅全部 GRX2 蛋白酶 -
纯度
> 90 % SDS-PAGE. -
表达系统
Saccharomyces cerevisiae -
蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Saccharomyces cerevisiae
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描述
重组S. cerevisiae GRX2蛋白
技术指标
Our Abpromise guarantee covers the use of ab63232 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Functional Studies
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形式
Liquid -
补充说明
This product was previously labelled as Glutaredoxin 2
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% Urea, 0.395% Tris HCl, 0.0292% EDTA, 50% Glycerol (glycerin, glycerine)
常规信息
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别名
- bA101E13.1
- bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2)
- CGI133
see all -
功能
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. -
组织特异性
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. -
序列相似性
Belongs to the glutaredoxin family.
Contains 1 glutaredoxin domain. -
细胞定位
Mitochondrion and Nucleus. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab63232 尚未被引用在任何文献中。