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AB236919

重组Ribosome inactivating蛋白alpha trichosanthin (Tagged)

Recombinant Ribosome inactivating protein alpha trichosanthin (Tagged)

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Recombinant Ribosome inactivating protein alpha trichosanthin (Tagged) is a Gua Lou Full Length protein, in the 24 to 270 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

查看别名

Ribosome-inactivating protein alpha-trichosanthin, Alpha-TCS, rRNA N-glycosidase

1 Images
SDS-PAGE - Recombinant Ribosome inactivating protein alpha trichosanthin (Tagged) (AB236919)
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Supplier Data

SDS-PAGE - Recombinant Ribosome inactivating protein alpha trichosanthin (Tagged) (AB236919)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel analysis of ab236919.

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

6x His tag N-Terminus SUMO tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

P09989

不含动物源

No

不含载体蛋白

No

种属

Gua Lou

存储溶液

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"DVSFRLSGATSSSYGVFISNLRKALPNERKLYDIPLLRSSLPGSQRYALIHLTNYADETISVAIDVTNVYIMGYRAGDTSYFFNEASATEAAKYVFKDAMRKVTLPYSGNYERLQTAAGKIRENIPLGLPALDSAITTLFYYNANSAASALMVLIQSTSEAARYKFIEQQIGKRVDKTFLPSLAIISLENSWSALSKQIQIASTNNGQFESPVVLINAQNQRVTITNVDAGVVTSNIALLLNRNNMA","proteinLength":"Full Length","predictedMolecularWeight":"43.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":270,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P09989","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Ribosome inactivating protein alpha trichosanthin also known as TCS is a type 1 ribosome-inactivating protein (RIP) that disrupts protein synthesis by depurinating adenine residues in ribosomal RNA. This action inhibits the assembly of the ribosome effectively halting protein synthesis. Trichosanthin exhibits a molecular weight of approximately 27 kDa. It is primarily expressed in the plant Trichosanthes kirilowii which belongs to the Cucurbitaceae family.
Biological function summary

Ribosome-inactivating proteins like trichosanthin possess a range of activities beyond protein synthesis inhibition. They participate in antiviral responses and have been investigated for their potential to target specific cellular processes in cancer cells. Trichosanthin does not function as part of a multimeric complex; rather it acts individually to exert its effects on cell machinery making it a subject of interest in cancer and virology research.

Pathways

Trichosanthin impacts cellular pathways that involve protein translation and antiviral defense mechanisms. Within these pathways it associates with cellular stress responses and modulates apoptosis. Trichosanthin is related to other ribosome-inactivating proteins such as ricin and saporin that share mechanistic similarities. These proteins interact with ribosomal components to trigger similar downstream effects and influence cellular homeostasis.

Ribosome inactivating protein alpha trichosanthin displays potential therapeutic effects against certain cancers and viral infections. It has shown promising results in research targeting HIV replication by impairing the virus's ability to hijack host cell machinery. Additionally it may be explored for its roles in modulating pathways involved in certain cancers. The protein's connection with other ribosome-inactivating proteins involves shared potential pathways for therapeutic intervention in diseases such as leukemia.
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特殊说明

形式

Liquid

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常规信息

功能

Inactivates eukaryotic 60S ribosomal subunits.

序列相似性

Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.

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产品实验方案

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靶点信息

Inactivates eukaryotic 60S ribosomal subunits.
See full target information Ribosome-inactivating protein alpha-trichosanthin
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