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AB288551

重组兔VEGFA蛋白

Recombinant Rabbit VEGFA protein

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Recombinant Rabbit VEGFA protein is a Full Length protein, in the 51 to 511 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

查看别名

Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, MGC70609, MVCD1, VEGF120, VEGFA_HUMAN, VPF, Vascular endothelial growth factor A, Vascular permeability factor, Vegf, vascular endothelial growth factor, vascular endothelial growth factor A121, vascular endothelial growth factor A165

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SDS-PAGE - Recombinant Rabbit VEGFA protein (AB288551)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Rabbit VEGFA protein (AB288551)

SDS PAGE analysis of ab288551.

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

6x His tag N-Terminus SUMO tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

不含动物源

No

不含载体蛋白

No

存储溶液

pH: 7.4 - 8 Constituents: 6% Trehalose, 2.9% Sodium chloride, 0.24% Tris

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB313996

Prestained Protein Ladder - Extra broad molecular weight (3 - 260 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3 - 260 kDa) (AB313996)

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Proteins & Peptides

AB259412

Recombinant human VEGF 165A protein (Active)

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Mass Spectrometry - Recombinant human VEGF 165A protein (Active) (AB259412)

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Proteins & Peptides

AB285462

Recombinant human FGF2 protein (Active)

Bioactive

Functional Studies - Recombinant human FGF2 protein (Active) (AB285462)

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Proteins & Peptides

AB259425

Recombinant human PDGF B protein (Active)

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Mass Spectrometry - Recombinant human PDGF B protein (Active) (AB259425)

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Secondary Antibodies

AB6759

Rabbit Anti-Human IgG H&L (HRP)

ELISA - Rabbit Anti-Human IgG H&L (HRP) (AB6759)

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  • 1
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"YLWLLHAPLLHVSLDSLVAAFSVVFEVLPSSLDIPGSKKEEQASTQLGGVEEEHEASGVVTRQLAFVVDAITNPTLEKETKTITRIHKAPKFPSHFGFWKRAEEERGGKSSGEKSRKTDGVGERAQAGEQREGPGQRAAALTDRQTDTAPSPSAHLLPGRRPTVDAAASGGQQPEPAPEGGVEGVGARGIALKLFVQLLGCSRSGGVVVRAGGAEPSGAARSVSSGREEPPPPPPEEEGEEEGEKEEERGPRWRLGAGEPGSWTGEAAVCADSAPAARAPQALARASAPGARGARGGAEESGPSRSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEEGDNKPHEVVKFMEVYRRSYCQPIETLVDIFQEYPDEIEYIFKPSCVPLVRCGGCCNDESLECVPTEEFNVTMQIMRIKPHQGQHIGEMSFLQHNKCECRCDKPRR","proteinLength":"Full Length","predictedMolecularWeight":"65.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":511,"aminoAcidStart":51,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":null,"tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Lyophilized
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Vascular endothelial growth factor A (VEGFA) also known as VEGF or vascular permeability factor (VPF) is a protein that plays a central role in angiogenesis as well as in the growth of blood vessels. The molecular weight of VEGFA varies depending on the isoform typically ranging from 34 to 42 kDa. VEGFA is expressed in many tissues including fibroblasts macrophages endothelial cells and platelets. Its expression levels can increase in response to stimuli like hypoxia or inflammatory cytokines. VEGFA is an important target in research for therapies related to vascular diseases and cancer.
Biological function summary

VEGFA functions by promoting the proliferation and migration of vascular endothelial cells. It operates both as a homodimer and as part of complex signaling cascades interacting with VEGF receptors on cell surfaces to trigger downstream signals for angiogenesis. This includes endothelial cell growth migration and the new blood vessel formation process. VEGFA's activity is important for physiological processes such as wound healing and embryonic development and it also contributes to pathological conditions through its unregulated expression in diseases.

Pathways

Many processes involve VEGFA including the PI3K/AKT pathway and the MAPK/ERK pathway. These pathways regulate cell survival growth and differentiation. Other proteins like PLGF (placenta growth factor) and VEGFB often accompany VEGFA in these pathways aiding in distinct but overlapping roles. These interactions are transmitted through binding to VEGF receptors such as VEGFR-1 and VEGFR-2 subsequently activating various signaling cascades necessary for cellular and tissue homeostasis.

VEGFA relates to cancer and age-related macular degeneration among others. In cancer overexpression of VEGFA can lead to excessive angiogenesis supplying blood to tumors and facilitating tumor growth. In age-related macular degeneration upregulation of VEGFA contributes to the progression of the disease by promoting the formation of abnormal blood vessels under the retina. Anti-VEGFA therapies such as anti-VEGF antibodies (e.g. bevacizumab) can target these overexpressed pathways. VEGFA interacts with other proteins like HIF-1α which regulates its expression under hypoxia a common condition in tumors.
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常规信息

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产品实验方案

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靶点信息

See full target information VEGFA
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