重组小鼠VEGFC蛋白(ab51947)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Suitable for: SDS-PAGE
描述
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产品名称
重组小鼠VEGFC蛋白
参阅全部 VEGFC 蛋白酶 -
纯度
> 90 % SDS-PAGE.
>90% by SDS-PAGE analyses. -
表达系统
Escherichia coli -
蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Mouse -
序列
HY NTEILKSIDN EWRKTQCMPR EVCIDVGKEF GAATNTFFKPPCVSVYRCGG CCNSEGLQCM NTSTGYLSKTLFEITVPLSQ GPKPVTISFANHTSCRCMSK LDVYRQVHSI IRR -
氨基酸
108 to 223
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技术指标
Our Abpromise guarantee covers the use of ab51947 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Lyophilized -
补充说明
This product is manufactured by BioVision, an Abcam company and was previously called 4634 VEGF-C, murine recombinant. 4634-10 is the same size as the 10 µg size of ab51947.
Reconstituted VEGFC should be stored in working aliquots at -80°C.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituent: 0.1% Acetic acid
50 µg BSA per 1 µg VEGFC -
复溶We recommend a quick spin followed by reconstitution in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml.
常规信息
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别名
- Flt 4L
- Flt4 ligand
- FLT4 ligand DHM
see all -
功能
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. -
组织特异性
Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. -
序列相似性
Belongs to the PDGF/VEGF growth factor family. -
翻译后修饰
Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. -
细胞定位
Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (1)
ab51947 被引用在 1 文献中.
- Nayar S et al. Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin a1ß2 in Newly Formed Tertiary Lymphoid Structures. J Immunol 197:1957-67 (2016). PubMed: 27474071
