AB316523

重组小鼠Tenascin C蛋白Standard (His tag)

Name: 重组小鼠Tenascin C蛋白Standard (His tag) (ab316523)| Abcam中文官网
Brand: Abcam Limited
SKU: AB316523
Price: 1406 CNY
Availability: InStock

Recombinant Mouse Tenascin C Protein Standard (His tag)

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Recombinant Mouse Tenascin C Protein Standard (His tag) is a Mouse Fragment protein, expressed in HEK 293 cells, with >80%, suitable for SDS-PAGE, sELISA.

查看别名

Hxb, Tnc, Tenascin, TN, Hexabrachion, Tenascin-C, TN-C

2 Images

Sandwich ELISA - Recombinant Mouse Tenascin C Protein Standard (His tag) (AB316523)

sELISA

Supplier Data

Sandwich ELISA - Recombinant Mouse Tenascin C Protein Standard (His tag) (AB316523)

Sandwich ELISA with the capture antibody dilution at 2 µg/mL and detector antibody dilution at 0.5 µg/mL.

SDS-PAGE - Recombinant Mouse Tenascin C Protein Standard (His tag) (AB316523)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse Tenascin C Protein Standard (His tag) (AB316523)

SDS-PAGE analysis of ab316523 under reducing conditions for 2ug protein.

关键信息

纯度

>80% SDS-PAGE

表达系统

HEK 293 cells

应用

sELISA, SDS-PAGE

applications

生物活性

访问

Q80YX1

不含动物源

Yes

不含载体蛋白

种属

Mouse

存储溶液

pH: 7.3 - 7.5 Constituents: 2.922% Sodium chloride, 0.64107% disodium;hydrogen phosphate;dodecahydrate, 0.02858% Potassium phosphate monobasic

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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产品详情

While the standard is the same as the one provided in the corresponding SimpleStep ELISA Kit, it cannot be treated as the consumable provided with our SimpleStep ELISA Kit due to differences in its concentration calibration.

Abcam guarantee that this protein standard is suitable for use in a sandwich ELISA. Individual results may vary due to differences in technique, laboratory equipment, buffers, and other experimental factors. The detection range provided for this protein standard is based on initial sandwich ELISA validation data.

The protein concentration is the concentration after validation on our sandwich ELISA platform. This Standard protein is guaranteed to work with our Capture and Detector antibodies in sELISA. Please contact our Scientific Support team to know which antibody pair is suitable for this protein.

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序列信息

[{"sequence":null,"proteinLength":"Fragment","predictedMolecularWeight":"60.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q80YX1","tags":[{"tag":"His","terminus":"C-Terminus"}]}]

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性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Tenascin C also known as hexabrachion is an extracellular matrix glycoprotein with a mass of approximately 220-300 kDa depending on post-translational modifications. It shows high expression in areas undergoing tissue remodeling such as embryonic tissues wounds and tumors. It consists of repeating structural elements including epidermal growth factor-like repeats and fibronectin type III domains which facilitate its function in the context of tissue dynamics.

Biological function summary

The large hexamer known as Tenascin C plays a significant role in modulating cell adhesion migration and proliferation especially during developmental processes and injury responses. It incorporates into the existing extracellular matrix as a loose network which provides elasticity and supports cellular activities. This feature allows Tenascin C to interact with other matrix molecules and cell surface receptors to regulate tissue morphogenesis.

Pathways

Tenascin C actively participates in the Wnt and TGF-beta signaling pathways important for controlling cellular behavior in development and regeneration. It associates with integrins and glycoproteins to influence cell responses to signaling events in these pathways. By modulating these interactions Tenascin C can impact processes such as epithelial-to-mesenchymal transition and angiogenesis affecting tissue architecture and function.

Tenascin C exhibits a strong connection to cancer progression and chronic inflammatory conditions such as rheumatoid arthritis. Its levels rise in tumors and inflamed tissues where it interacts with other matrix components and cytokines like interleukin-6 (IL-6). These interactions contribute to a microenvironment that promotes tumor growth and persistence of inflammation highlighting its role in the pathophysiology of these diseases.

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特殊说明

形式

Liquid

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常规信息

功能

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8 : ITGB1, ITGA9 : ITGB1, ITGAV : ITGB3 and ITGAV : ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).

序列相似性

Belongs to the tenascin family.

翻译后修饰

N-glycosylated.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information Tnc

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Abcam Product Promise

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详情请参阅我们的条款与条件。

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重组小鼠Tenascin C蛋白Standard (His tag)

Recombinant Mouse Tenascin C Protein Standard (His tag)

Sandwich ELISA - Recombinant Mouse Tenascin C Protein Standard (His tag) (AB316523)

SDS-PAGE - Recombinant Mouse Tenascin C Protein Standard (His tag) (AB316523)

关键信息

纯度

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液