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AB93068

重组小鼠PAI1蛋白

Recombinant mouse PAI1 protein

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(1 Publication)

Recombinant mouse PAI1 protein is a Mouse Full Length protein, in the 24 to 402 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, FuncS.

查看别名

Mr1, Pai1, Planh1, Serpine1, Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1

1 Images
SDS-PAGE - Recombinant mouse PAI1 protein (AB93068)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant mouse PAI1 protein (AB93068)

10% SDS-PAGE
Lane 1 : PAI1 (5 μg) Reduced
Lane 2 : PAI1 (5 μg) +uPA-HTC (8 μg) Reduced
Lane 3 : Prestained Standard

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

标签

Tag free

应用

SDS-PAGE, FuncS

applications

生物活性

Yes

生物学活性

ab93068 is 80 (+/-) 5% active by uPA titration. The active fraction typically contains 70 percent active PAI1. Active concentration = ~2.0 mg/mL.

访问

P22777

不含动物源

No

不含载体蛋白

No

种属

Mouse

存储溶液

pH: 5 Constituents: 0.58% Sodium chloride, 0.41% Sodium acetate, 0.0292% EDTA

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"LPLRESHTAHQATDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTAHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVERARFIINDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRLFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLSALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLSDQEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNPTETILFMGQVMEP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P22777","tags":[]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
True
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特殊说明

形式

Liquid

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常规信息

功能

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed : 16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed : 28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

序列相似性

Belongs to the serpin family.

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产品实验方案

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靶点信息

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed : 16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed : 28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
See full target information Serpine1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 14:e0221366 PubMed31442231

2019

Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Shunshun Zhu,Zhe Tian,Daisuke Torigoe,Jiabin Zhao,Peiyu Xie,Taichi Sugizaki,Michio Sato,Haruki Horiguchi,Kazutoyo Terada,Tsuyoshi Kadomatsu,Keishi Miyata,Yuichi Oike
View all publications
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搭配使用产品

Primary Antibodies

AB66705

Anti-PAI1 antibody

BOND RX™ Validated

Western blot - Anti-PAI1 antibody (AB66705)

  • 4
  • 8
Assay Kits

AB242296

Gamma H2A.X Staining Kit

Fluorescence Microscopy - Gamma H2A.X Staining Kit (AB242296)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

  • 0
  • 0

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