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AB276896

重组小鼠IFNA14蛋白(His tag)

Recombinant mouse IFNA14 protein (His tag)

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Recombinant mouse IFNA14 protein (His tag) is a Full Length protein, in the 24 to 189 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
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Functional Studies - Recombinant mouse IFNA14 protein (His tag) (AB276896)
  • FuncS

Supplier Data

Functional Studies - Recombinant mouse IFNA14 protein (His tag) (AB276896)

Measured in antiviral assay using L929 cells infected with vesicular stomatitisvirus (VSV).
The ED50 for this effect is typically 5-40 pg/mL.

SDS-PAGE - Recombinant mouse IFNA14 protein (His tag) (AB276896)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant mouse IFNA14 protein (His tag) (AB276896)

SDS-PAGE analysis of ab276896

关键信息

纯度

>90% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

HEK 293 cells

标签

His tag C-Terminus

应用

FuncS, SDS-PAGE

applications

生物活性

Yes

生物学活性

Measured in antiviral assay using L929 cells infected with vesicular stomatitisvirus (VSV).
The ED50 for this effect is typically 5-40 pg/mL.

不含动物源

No

不含载体蛋白

No

存储溶液

pH: 7.4 Constituents: 100% PBS

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"CDLPQTHNLRNKRALTLLVKMRRLSPLSCLKDRKDFGFPQEKVDAQQIKKAQAIPVLSELTQQILTLFTSKDSSAAWDATLLDSFCNDLNTQLNDLQGCLMQQVEIQAPPLTQEDSLLAVRKYFHRITVYLREKKHSPCAWEVVRAEIWRALSSSAKLLTSLKEEK","proteinLength":"Full Length","predictedMolecularWeight":"20.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":189,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":null,"tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
True
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

IFNA14 also known as Interferon Alpha-14 is a low molecular weight protein weighing approximately 19.3 kDa. It belongs to the type I interferon family and functions as a cytokine. IFNA14 is primarily expressed in leukocytes where it exerts its effects on various immune responses. This protein contributes to the antiviral boundaries of cells by binding to specific cell-surface receptors.
Biological function summary

IFNA14 plays an essential role in the immune system response to viral infections. It interacts with the type I interferon receptor complex to activate transcription of interferon-stimulated genes which help to mediate antiviral effects. IFNA14 signals through the JAK-STAT pathway ultimately leading to an increased expression of MHC class I antigens and enhanced immune recognition. Its activity aids in the coordination of the immune system's efforts to combat viral pathogens.

Pathways

IFNA14 is integral to the interferon signaling pathway and plays a part in the innate immune response pathway. These pathways involve a cascade of proteins including JAK1 and STAT2 which mediate its signal transduction. The activation of these pathways leads to transcriptional changes necessary for an effective antiviral state and modulation of the immune response.

IFNA14 has connections with viral infections like Hepatitis C and systemic lupus erythematosus (SLE). Its dysregulation or overexpression can lead to an inappropriate immune response contributing to the pathogenesis of these conditions. The relationship between IFNA14 and other interferon-induced proteins such as IRF7 highlights its significance in disease progression and points to potential therapeutic targets.
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特殊说明

形式

Lyophilized

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常规信息

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产品实验方案

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靶点信息

See full target information IFNA14
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搭配使用产品

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