重组小鼠Hsp27蛋白
Recombinant Mouse Hsp27 protein
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(1 Publication)
Recombinant Mouse Hsp27 protein is a Mouse Full Length protein, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, WB.
查看别名
Hsp25, Hsp27, Hspb1, Heat shock protein beta-1, HspB1, Growth-related 25 kDa protein, Heat shock 25 kDa protein, Heat shock 27 kDa protein, p25, HSP 25, HSP 27
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Mouse Hsp27 protein (AB92457)
SDS-PAGE Analysis :
Lane 1 : Molecular weight marker
Lane 2 : 0.5 μg ab92457
Lane 3 : 1.0 μg ab92457
Lane 4 : 2.0 μg ab92457
Lane 5 : 5.0 μg ab92457
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Hsp27 plays a critical role in cellular stress response by regulating actin cytoskeleton dynamics and inhibiting apoptosis. It forms part of a complex that includes other proteins such as alphaB-crystallin. This complex facilitates the reorganization of proteins under stress conditions enhancing cell survival during oxidative stress or thermal shock. Hsp27 also modulates inflammatory responses and has been shown to affect cell migration.
Pathways
Hsp27 integrates into the apoptosis and inflammation pathways. It interacts with apoptotic machinery such as caspase proteins to protect cells by hindering apoptosome formation. Additionally Hsp27 can engage with pathways involving the nuclear factor-kappa B (NF-kB) impacting inflammatory signaling. CPTC (carboxyl-pyrene-trioctylamine) can modulate these pathways by altering Hsp27 function and interactions.
特殊说明
形式
Liquid
附加说明
Purified by multi-step chromatography.> 90% pure as determined by SDS-PAGE and Western Blot analysis.
常规信息
功能
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed : 17661394). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).
序列相似性
Belongs to the small heat shock protein (HSP20) family.
翻译后修饰
Phosphorylated upon exposure to protein kinase C activators and heat shock (By similarity). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:1860870, PubMed:21575178, PubMed:8093612).
亚细胞定位
Nucleus
产品实验方案
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靶点信息
文献 (1)
Recent publications for all applications. Explore the full list and refine your search
OncoTargets and therapy 11:395-408 PubMed29403285
2018
Applications
Unspecified application
Species
Unspecified reactive species
Abcam Product Promise
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