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AB271531

重组小鼠 Glycogenin 1 + GYS1 蛋白 (Strep tag C-Terminus, His tag N-Terminus)

Recombinant Mouse Glycogenin 1 + GYS1 protein (Strep tag C-Terminus, His tag N-Terminus)

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Recombinant Mouse Glycogenin 1 + GYS1 protein (Strep tag C-Terminus, His tag N-Terminus) is a Mouse Full Length protein, in the 1 to 738 aa range, expressed in Baculovirus infected Sf9 cells, with >68%, suitable for SDS-PAGE.

查看别名

Gyg, Gyg1, Glycogenin-1, GN-1, GN1, Gys, Gys3, Gys1, Glycogen synthase 1

1 Images
SDS-PAGE - Recombinant Mouse Glycogenin 1 + GYS1 protein (Strep tag C-Terminus, His tag N-Terminus) (AB271531)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse Glycogenin 1 + GYS1 protein (Strep tag C-Terminus, His tag N-Terminus) (AB271531)

SDS-PAGE analysis of 4 μg ab271531.

关键信息

纯度

>68% SDS-PAGE

Affinity purified.

表达系统

Baculovirus infected Sf9 cells

标签

Tag free

应用

SDS-PAGE

applications

生物活性

No

访问

Q9R062

不含动物源

No

不含载体蛋白

No

种属

Mouse

存储溶液

pH: 8 Preservative: 1.7% Imidazole Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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搭配使用产品

Primary Antibodies

AB272606

Anti-Glycogenin 1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Glycogenin 1 antibody (AB272606)

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Proteins & Peptides

AB116414

Recombinant Human EMILIN1 protein (6x His)

Western blot - Recombinant Human EMILIN1 protein (6x His) (AB116414)

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Proteins & Peptides

AB100986

Recombinant Human QPRT protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human QPRT protein (His tag N-Terminus) (AB100986)

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Assay Kits

AB242296

Gamma H2A.X Staining Kit

Fluorescence Microscopy - Gamma H2A.X Staining Kit (AB242296)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MPLSRSLSVSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN","proteinLength":"Full Length","predictedMolecularWeight":"85 kDa","actualMolecularWeight":null,"aminoAcidEnd":738,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q9Z1E4","tags":[{"tag":"Strep","terminus":"C-Terminus"}]},{"linker":null,"sequence":"MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRMVVLTSPQVSDSMRKVLETVFDDVIMVDVLDSGDSAHLTLMKRPELGITLTKLHCWSLTQYSKCVFMDADTLVLSNIDDLFEREELSAAPDPGWPDCFNSGVFVYQPSIETYNQLLHLASEQGSFDGGDQGLLNTYFSGWATTDITKHLPFVYNLSSISIYSYLPAFKAFGKNAKVVHFLGRTKPWNYTYNPQTKSVNCDSQDPTVSHPEFLNLWWDTFTTNVLPLLQHHGLVKDASSYLMMEHVSGALSDLSFGEAPAAPQPSMSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ","proteinLength":"Full Length","predictedMolecularWeight":"40 kDa","actualMolecularWeight":null,"aminoAcidEnd":333,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q9R062","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification
运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Glycogen synthase 1 also known as GYS1 and Glycogenin 1 is an enzyme primarily responsible for conversion of glucose into glycogen. It acts by catalyzing the addition of glucose units from UDP-glucose to growing glycogen chains adding to the energy storage in cells. GYS1 has a molecular mass of approximately 85 kDa. Expression of this protein mainly occur in muscle and liver tissues where glycogen storage is important for energy management exhibiting an important role in these tissues.
Biological function summary

GYS1 functions as the primary enzyme responsible for glycogen synthesis within cells. This enzyme operates in a complex with glycogenin which serves as the primer necessary for glycogen biosynthesis initiation. The association ensures the formation of a glycogen molecule by elongating the glucose chain. Through this mechanism GYS1 enables the formation of substantial glycogen reserves essential for energy demand particularly in cells with high energy needs like muscle cells.

Pathways

The function of GYS1 integrates into the glycogenesis pathway allowing cells to effectively store glucose as glycogen. As part of this pathway GYS1 works alongside glycogen phosphorylase which breaks down glycogen during times of energy need. GYS1 activity is regulated by insulin signaling highlighting its connection to the the insulin signaling pathway which controls glucose metabolism. This regulation allows the cell to maintain energy homeostasis linking GYS1 to broader metabolic pathways.

Mutations and irregularities within the GYS1 gene can lead to conditions such as Glycogen Storage Disease type 0 and Type 2 Diabetes. Glycogen Storage Disease type 0 manifests due to a deficiency in glycogen synthase leading to fasting hypoglycemia and reduced glycogen in the liver. GYS1 also links to insulin signaling malfunctions making it relevant to the development of diabetes. This connection to disorders highlights its importance beside proteins like glycogen phosphorylase and insulin receptors in maintaining proper glucose and glycogen balance within the body.
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常规信息

功能

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.

序列相似性

Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.

翻译后修饰

Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.. Phosphorylated.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
See full target information Gyg1
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