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AB276804

重组小鼠DECTIN 2蛋白(His tag)

Recombinant Mouse DECTIN 2 protein (His tag)

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Recombinant Mouse DECTIN 2 protein (His tag) is a Mouse Fragment protein, in the 44 to 209 aa range, expressed in HEK 293 cells, with >97%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

Clec4n, Clecsf10, Dectin2, Clec6a, C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dendritic cell-associated C-type lectin 2, DC-associated C-type lectin 2, Dectin-2

1 Images
SDS-PAGE - Recombinant Mouse DECTIN 2 protein (His tag) (AB276804)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse DECTIN 2 protein (His tag) (AB276804)

SDS-PAGE analysis of ab276804

关键信息

纯度

>97% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

HEK 293 cells

标签

His tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q9JKF4

不含动物源

No

不含载体蛋白

No

种属

Mouse

存储溶液

pH: 7.4 Constituents: PBS

storage-buffer

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搭配使用产品

Primary Antibodies

AB1316

Anti-VEGFA antibody [VG-1]

BOND RX™ Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFA antibody [VG-1] (AB1316)

  • 4
  • 45
Primary Antibodies

AB107572

Anti-DECTIN 2 antibody [IMG3D1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DECTIN 2 antibody [IMG3D1] (AB107572)

  • 0
  • 0
Primary Antibodies

AB32152

Anti-VEGF Receptor 1 antibody [Y103]

RabMAb|Recombinant|20ul selling size

Immunoprecipitation - Anti-VEGF Receptor 1 antibody [Y103] (AB32152)

  • 5
  • 21
Primary Antibodies

AB2349

Anti-VEGF Receptor 2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGF Receptor 2 antibody (AB2349)

  • 4
  • 17
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"IMDQPSRRLYELHTYHSSLTCFSEGTMVSEKMWGCCPNHWKSFGSSCYLISTKENFWSTSEQNCVQMGAHLVVINTEAEQNFITQQLNESLSYFLGLSDPQGNGKWQWIDDTPFSQNVRFWHPHEPNLPEERCVSIVYWNPSKWGWNDVFCDSKHNSICEMKKIYL","proteinLength":"Fragment","predictedMolecularWeight":"20.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":209,"aminoAcidStart":44,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9JKF4","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

形式
Lyophilized
运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

DECTIN-2 also known as C-type lectin domain family 6 member A (CLEC6A) is a cell surface receptor that belongs to the C-type lectin family. It plays a significant role in the immune system by recognizing and binding to polysaccharides found on the surface of fungi such as alpha-mannans. DECTIN-2 is a type II transmembrane protein with an approximate molecular mass of 28 kDa. It is expressed mostly in dendritic cells and macrophages where it helps initiate immune responses against fungal pathogens.
Biological function summary

DECTIN-2 is a part of the innate immune system functioning through its association with the Fc receptor gamma chain to form a signaling complex. This interaction allows DECTIN-2 to transmit signals that lead to the activation of the NF-kB pathway which in turn stimulates the production of pro-inflammatory cytokines. The role of DECTIN-2 extends to influencing adaptive immunity as it helps in the maturation of dendritic cells and the proliferation of antigen-specific T cells.

Pathways

The DECTIN-2-mediated signaling integrates into the broader pattern recognition receptor pathways notably the C-type lectin receptor signaling pathway and the complement cascade. DECTIN-2 interacts closely with other proteins like DECTIN-1 another C-type lectin and complement protein C3 which together coordinate a more comprehensive immune response. These interactions enhance pathogen recognition and clearance emphasizing DECTIN-2's important position within the immune surveillance system.

DECTIN-2 is particularly relevant in conditions such as fungal infections and autoimmune diseases. In fungal infections DECTIN-2 together with DECTIN-1 enhances the body's ability to detect and respond to pathogenic fungi reducing infection severity. Additionally abnormal DECTIN-2 signaling or expression may contribute to autoimmune disorders such as rheumatoid arthritis where overactive immune responses cause tissue damage. Understanding DECTIN-2's role could provide insight into potential therapeutic targets for managing these diseases.
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常规信息

功能

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system : specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed : 17050534, PubMed : 19703985, PubMed : 20493731). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed : 17050534, PubMed : 19703985, PubMed : 20493731, PubMed : 32358020). Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (PubMed : 19124755). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (PubMed : 21059925).

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产品实验方案

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靶点信息

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system : specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed : 17050534, PubMed : 19703985, PubMed : 20493731). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed : 17050534, PubMed : 19703985, PubMed : 20493731, PubMed : 32358020). Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (PubMed : 19124755). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (PubMed : 21059925).
See full target information Clec6a
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