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AB316428

Recombinant Mouse CYR61 Protein Standard (His tag)

Recombinant Mouse CYR61 Protein Standard (His tag)

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Recombinant Mouse CYR61 Protein Standard (His tag) is a Mouse Full Length protein, expressed in HEK 293 cells, with >80%, suitable for sELISA, SDS-PAGE.

查看别名

Cyr61, Igfbp10, Kiaa0083, Dna2l, Dna2, CCN family member 1, 3CH61, Cellular communication network factor 1, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10, Protein CYR61, IBP-10, IGF-binding protein 10, IGFBP-10

2 Images
Sandwich ELISA - Recombinant Mouse CYR61 Protein Standard (His tag) (AB316428)
  • sELISA

Supplier Data

Sandwich ELISA - Recombinant Mouse CYR61 Protein Standard (His tag) (AB316428)

Sandwich ELISA with the capture antibody dilution at 2 µg/mL and detector antibody dilution at 0.5 µg/mL

SDS-PAGE - Recombinant Mouse CYR61 Protein Standard (His tag) (AB316428)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse CYR61 Protein Standard (His tag) (AB316428)

SDS-PAGE analysis of ab316428.

关键信息

纯度

>80% SDS-PAGE

表达系统

HEK 293 cells

标签

His tag C-Terminus

应用

SDS-PAGE, sELISA

applications

生物活性

No

访问

P18406

不含动物源

Yes

不含载体蛋白

No

种属

Mouse

存储溶液

pH: 7.3 - 7.5 Constituents: 2.922% Sodium chloride, 0.64107% disodium;hydrogen phosphate;dodecahydrate, 0.02858% Potassium phosphate monobasic

storage-buffer

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搭配使用产品

Proteins & Peptides

AB105607

Recombinant Human S100A16 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human S100A16 protein (His tag N-Terminus) (AB105607)

  • 0
  • 0
Assay Kits

AB238267

Human CYR61 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human CYR61 ELISA Kit (AB238267)

  • 0
  • 0
Primary Antibodies

AB228592

Anti-CYR61/CCN1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CYR61/CCN1 antibody (AB228592)

  • 0
  • 0
Proteins & Peptides

AB283423

Recombinant Human Fibronectin protein

Mass Spectrometry - Recombinant Human Fibronectin protein (AB283423)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

While the standard is the same as the one provided in the corresponding SimpleStep ELISA Kit, it cannot be treated as the consumable provided with our SimpleStep ELISA Kit due to differences in its concentration calibration.

Abcam guarantee that this protein standard is suitable for use in a sandwich ELISA. Individual results may vary due to differences in technique, laboratory equipment, buffers, and other experimental factors. The detection range provided for this protein standard is based on initial sandwich ELISA validation data.

The protein concentration is the concentration after validation on our sandwich ELISA platform. This Standard protein is guaranteed to work with our Capture and Detector antibodies in sELISA. Please contact our Scientific Support team to know which antibody pair is suitable for this protein.

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序列信息

[{"linker":null,"sequence":null,"proteinLength":"Full Length","predictedMolecularWeight":"63.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P18406","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification His Tag
运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CYR61 also known as CCN1 is a secreted protein involved in cell signaling. It belongs to the CCN family of proteins and weighs approximately 42 kDa. This protein is found in various tissues including the skin lungs and blood vessels. CYR61 is involved in cellular activities such as adhesion migration and proliferation by interacting with cell surface receptors. This active participation in cell signaling makes CYR61 essential to multiple cellular processes.
Biological function summary

CYR61 supports angiogenesis and wound healing by promoting cell survival and adhesion. It functions as a significant component of the extracellular matrix and often participates in complex formations with other CCN proteins. These complexes aid in mediating interactions between cells and their environments. Through these mechanisms CYR61 influences various biological outcomes impacting how tissues grow and repair.

Pathways

CYR61 contributes to both the integrin and TGF-beta signaling pathways. In the integrin pathway it interacts with proteins like integrin alphaVbeta3 to influence cell movement and survival. The TGF-beta pathway involves its regulation of cellular responses to growth factors. By playing important roles in these pathways CYR61 maintains essential cellular functions and intercellular communication impacting diverse physiological processes.

CYR61 has links to cancer and fibrosis. Its overexpression can contribute to tumor progression and metastasis often in connection with matrix metalloproteinases during cancer development. In fibrosis CYR61 collaborates with fibroblast growth factor receptors to promote tissue scarring and stiffness. These connections highlight the importance of CYR61 in pathological conditions offering potential targets for therapeutic intervention.
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常规信息

功能

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).

序列相似性

Belongs to the CCN family.

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产品实验方案

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靶点信息

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).
See full target information Ccn1
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