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AB181905

重组人 ZCCHC12 蛋白 (denatured) (His tag N-Terminus)

Recombinant Human ZCCHC12 protein (denatured) (His tag N-Terminus)

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Recombinant Human ZCCHC12 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 402 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

SIZN1, ZCCHC12, Zinc finger CCHC domain-containing protein 12, Smad-interacting zinc finger protein 1

1 Images
SDS-PAGE - Recombinant Human ZCCHC12 protein (denatured) (His tag N-Terminus) (AB181905)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ZCCHC12 protein (denatured) (His tag N-Terminus) (AB181905)

15% SDS-PAGE analysis of 3ug ab181905 stained with Coomassie Blue.

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q6PEW1

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMASIIARVGNSRRLNAPLPPWAHSMLRSLGRSLGPIMASMADRNMKLFSGRVVPAQGEETFENWLTQVNGVLPDWNMSEEEKLKRLMKTLRGPAREVMRVLQATNPNLSVADFLRAMKLVFGESESSVTAHGKFFNTLQAQGEKASLYVIRLEVQLQNAIQAGIIAEKDANRTRLQQLLLGGELSRDLRLRLKDFLRMYANEQERLPNFLELIRMVREEEDWDDAFIKRKRPKRSESMVERAVSPVAFQGSPPIVIGSADCNVIEIDDTLDDSDEDVILVESQDPPLPSWGAPPLRDRARPQDEVLVIDSPHNSRAQFPSTSGGSGYKNNGPGEMRRARKRKHTIRCSYCGEEGHSKETCDNESDKAQVFENLIITLQELTHTEMERSRVAPGEYNDFSEPL","proteinLength":"Full Length","predictedMolecularWeight":"45 kDa","actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q6PEW1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZCCHC12 also known as zinc finger CCHC domain-containing protein 12 is a protein that plays a significant role in transcriptional regulation. This protein has a mass of approximately 64 kDa and is widely expressed in various tissues with significant levels found in the brain. It contains CCHC-type zinc finger domains that facilitate its interaction with nucleic acids contributing to its regulatory functions. The gene encoding ZCCHC12 is located on chromosome 15 and its expression patterns suggest an involvement in neural activity and development.
Biological function summary

ZCCHC12 influences gene expression by participating in RNA processing activities. It is not known to be part of a larger complex but acts independently to modulate the stability and translation of specific mRNA transcripts. Research indicates its involvement in maintaining neuronal homeostasis as it directly influences synaptic function and plasticity. The protein's role in regulating neuronal gene expression is important for normal central nervous system function.

Pathways

The protein interacts with molecular mechanisms such as the JAK-STAT signaling pathway and the mTOR pathway both important for cellular growth and immune response. Within these pathways ZCCHC12 often interacts with proteins like STAT3 and mTOR which play roles in cell proliferation and metabolism. These interactions underline its importance in maintaining cellular architecture and functional dynamics.

ZCCHC12 shows connections to neurological disorders particularly those related to cognitive impairment and neurodegenerative diseases. Altered expression or mutations in the ZCCHC12 gene is associated with conditions such as Alzheimer's disease and specific forms of epilepsy. Through these diseases ZCCHC12 interplays with proteins like tau and amyloid precursor protein (APP) which are key in disease pathogenesis. Understanding ZCCHC12's role offers insights into potential therapeutic targets for these complex diseases.

常规信息

功能

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).

序列相似性

Belongs to the ZCCHC12 family.

产品实验方案

靶点信息

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).
See full target information ZCCHC12

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