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AB289731

重组人VHL蛋白

Recombinant Human VHL Protein

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Recombinant Human VHL Protein is a Human Full Length protein, in the 1 to 213 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL

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HPLC - Recombinant Human VHL Protein (AB289731)
  • HPLC

Supplier Data

HPLC - Recombinant Human VHL Protein (AB289731)

HPLC analysis of ab289731

SDS-PAGE - Recombinant Human VHL Protein (AB289731)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human VHL Protein (AB289731)

SDS-PAGE analysis of ab289731

关键信息

纯度

>95% SDS-PAGE

内毒素水平

<0.005 EU/µg

表达系统

HEK 293 cells

标签

Tag free

应用

SDS-PAGE

applications

生物活性

No

访问

P40337

不含动物源

Yes

不含载体蛋白

No

种属

Human

复溶

Reconstitute in PBS

存储溶液

pH: 7.4 Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB325995

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands) (AB325995)

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Sample Prep & Detection Kits

AB201795

Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link®

ELISA - Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link® (AB201795)

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Proteins & Peptides

AB162449

Recombinant Human CRBN protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human CRBN protein (GST tag N-Terminus) (AB162449)

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Proteins & Peptides

AB271497

Recombinant human Elongin-B + Elongin C + VHL protein (DDDDK tag N-Terminus, His tag N-Terminus)

Functional Studies - Recombinant human Elongin-B + Elongin C + VHL protein (DDDDK tag N-Terminus, His tag N-Terminus) (AB271497)

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Proteins & Peptides

AB271787

Recombinant Human CUL-2 + Elongin-B + Elongin-C + RBX1 + VHL protein (6x His N-Term, DDDDK N-Term)

Functional Studies - Recombinant Human CUL-2 + Elongin-B + Elongin-C + RBX1 + VHL protein (6x His N-Term, DDDDK N-Term) (AB271787)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD","proteinLength":"Full Length","predictedMolecularWeight":"24.21 kDa","actualMolecularWeight":null,"aminoAcidEnd":213,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P40337","tags":[]}]
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性能和储存信息

形式
Lyophilized
运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
False
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常规信息

功能

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed : 10944113, PubMed : 17981124, PubMed : 19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed : 10944113, PubMed : 17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed : 10944113, PubMed : 17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed : 19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed : 34290272).

序列相似性

Belongs to the VHL family.

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产品实验方案

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靶点信息

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed : 10944113, PubMed : 17981124, PubMed : 19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed : 10944113, PubMed : 17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed : 10944113, PubMed : 17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed : 19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed : 34290272).
See full target information VHL
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