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AB171691

重组人 UQCRQ 蛋白 (denatured) (His tag N-Terminus)

Recombinant Human UQCRQ protein (denatured) (His tag N-Terminus)

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Recombinant Human UQCRQ protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 82 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

Cytochrome b-c1 complex subunit 8, Complex III subunit 8, Complex III subunit VIII, Ubiquinol-cytochrome c reductase complex 9.5 kDa protein, Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C, UQCRQ

1 Images
SDS-PAGE - Recombinant Human UQCRQ protein (denatured) (His tag N-Terminus) (AB171691)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human UQCRQ protein (denatured) (His tag N-Terminus) (AB171691)

15% SDS-PAGE analysis of ab171691 (3µg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

O14949

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMGREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIYTWGTEEFERSKRKNPAAYENDK","proteinLength":"Full Length","predictedMolecularWeight":"12.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":82,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O14949","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The UQCRQ protein also known as the ubiquinol-cytochrome c reductase complex III subunit VII has a mass of approximately 9.5 kDa. It is a component of the mitochondrial respiratory chain complex III. This protein is expressed in various tissues throughout the body with a higher concentration in tissues that require substantial energy production. UQCRQ plays a mechanical role in the electron transport chain facilitating the transfer of electrons between coenzyme Q and cytochrome c. This process contributes to the proton gradient used by ATP synthase for ATP synthesis.
Biological function summary

UQCRQ is a part of the cytochrome bc1 complex which is a critical enzyme in the mitochondrial inner membrane. This complex is essential in cellular respiration helping in the conversion of energy from nutrients into usable cellular energy in the form of ATP. The activity of UQCRQ is important for maintaining the efficiency of this larger complex and any disruption can significantly affect cellular energy homeostasis. UQCRQ supports the integrity of mitochondrial function impacting both energy production and reactive oxygen species management.

Pathways

UQCRQ is pivotal in oxidative phosphorylation and the electron transport chain specifically within the mitochondrial respiratory complex III. It works closely with other proteins in the complex such as cytochrome b and cytochrome c1 ensuring efficient electron transfer. Through these pathways UQCRQ contributes to oxidative stress regulation and cellular energy metabolism linking energy-producing mechanisms to broader cellular processes like apoptosis and cell growth.

UQCRQ has associations with mitochondrial disorders and myopathies. Mutations or dysfunctions in UQCRQ can lead to impaired energy production manifesting in conditions like mitochondrial encephalomyopathy and hypertrophic cardiomyopathy. The dysfunction in UQCRQ can affect proteins such as cytochrome c which plays a role in apoptosis potentially leading to neurodegenerative changes seen in mitochondrial-related diseases. Understanding the implications of UQCRQ in these conditions can guide the development of therapeutic strategies targeting mitochondrial dysfunction.
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特殊说明

形式

Liquid

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常规信息

功能

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.

序列相似性

Belongs to the UQCRQ/QCR8 family.

亚细胞定位

Mitochondrion inner membrane

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产品实验方案

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靶点信息

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
See full target information UQCRQ
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