重组人 UBR1 蛋白 (GST tag N-Terminus)
Recombinant Human UBR1 protein (GST tag N-Terminus)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human UBR1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 2 to 100 aa range, expressed in Wheat germ, suitable for ELISA, WB.
查看别名
E3 ubiquitin-protein ligase UBR1, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human UBR1 protein (GST tag N-Terminus) (AB165841)
ab165841 on a 12.5% SDS-PAGE stained with Coomassie Blue.
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
In cellular regulation and homeostasis UBR1 plays a critical role. As a part of the larger ubiquitin-proteasome system it maintains protein quality control and modulates turnover rates of key proteins which ensures normal cellular functions. Although not directly a part of a complex it interacts with other UBR family members like UBR2 under overlapping pathways which can influence the degradation of specific proteins thereby impacting various signaling cascades.
Pathways
UBR1 is an integral regulator within the proteolytic pathways particularly the N-end rule pathway and ubiquitin-mediated proteolysis. In the N-end rule pathway it cooperates closely with other components like UBR2 which together target specific substrates for degradation therefore impacting processes like cell cycle regulation and stress responses. These pathways ensure balanced protein levels influencing processes such as cell growth and apoptosis vital for maintaining cellular integrity.
特殊说明
形式
Liquid
常规信息
功能
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed : 15548684, PubMed : 16311597, PubMed : 18162545, PubMed : 20835242, PubMed : 28392261). Recognizes and binds proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed : 18162545, PubMed : 20835242, PubMed : 28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed : 18162545). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed : 20835242). In contrast, it strongly binds methylated N-degrons (PubMed : 28392261). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed : 20298436).
序列相似性
Belongs to the E3 ubiquitin-protein ligase UBR1-like family.
靶点信息
搭配使用产品
Abcam Product Promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com