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AB167938

重组人UBE2Z蛋白

Recombinant Human UBE2Z protein

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Recombinant Human UBE2Z protein is a Human Fragment protein, in the 109 to 354 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, WB.

查看别名

HOYS7, UBE2Z, Ubiquitin-conjugating enzyme E2 Z, E2 ubiquitin-conjugating enzyme Z, Uba6-specific E2 conjugating enzyme 1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z, Use1

1 Images
SDS-PAGE - Recombinant Human UBE2Z protein (AB167938)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human UBE2Z protein (AB167938)

SDS Page analysis of ab167938

关键信息

纯度

>80% Densitometry

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

WB, SDS-PAGE

applications

生物活性

No

访问

Q9H832

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7 Preservative: 1.02% Imidazole Constituents: 25% Glycerol (glycerin, glycerine), 1.75% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV","proteinLength":"Fragment","predictedMolecularWeight":"30 kDa","actualMolecularWeight":null,"aminoAcidEnd":354,"aminoAcidStart":109,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H832","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

UBE2Z also known as Ubiquitin-Conjugating Enzyme E2 Z is an enzyme that plays a mechanical role in the ubiquitination process. This enzyme belongs to the E2 ubiquitin-conjugating enzyme family. UBE2Z has a mass of approximately 37.5 kDa. It is expressed in various tissues including but not limited to the liver heart and skeletal muscle. The enzyme catalyzes the transfer of ubiquitin from an E1 ubiquitin-activating enzyme to E3 ubiquitin ligases facilitating substrate ubiquitination.
Biological function summary

UBE2Z is involved in protein degradation and regulation of protein homeostasis. It is an important part of the ubiquitin-proteasome system ensuring damaged or misfolded proteins are marked for degradation. UBE2Z can function independently or in conjunction with multi-protein complexes. It has an important role in regulating cellular processes like cell cycle progression DNA repair and response to stress. Additionally it contributes to the regulation of several cellular pathways through these processes.

Pathways

UBE2Z is significantly involved in the protein ubiquitination pathway and cellular response to oxidative stress. In the protein ubiquitination pathway it interacts with various E3 ligases influencing protein turnover. Notably it interacts with the KEAP1 pathway which regulates the degradation of NRF2 a transcription factor involved in antioxidative responses. UBE2Z’s association with these pathways links it to the modulation of protein stability and cellular sensitivity to oxidative damage.

UBE2Z has been linked to metabolic disorders and renal diseases. Research has shown that variations in the UBE2Z gene have associations with obesity-related traits and Type 2 diabetes. The enzyme also has connections to proteins like NRF2 and KEAP1 which play roles in the development of renal pathologies. Dysregulation in UBE2Z activity can contribute to oxidative stress and inflammation further influencing disease progression in these disorders.
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特殊说明

形式

Liquid

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常规信息

功能

Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.

序列相似性

Belongs to the ubiquitin-conjugating enzyme family.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.
See full target information UBE2Z
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