重组人 Tyrosyl tRNA synthetase/TyrRS 蛋白 (His tag N-Terminus)
Recombinant Human Tyrosyl tRNA synthetase/TyrRS protein (His tag N-Terminus)
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Recombinant Human Tyrosyl tRNA synthetase/TyrRS protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 528 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
查看别名
YARS, YARS1, Tyrosyl-tRNA synthetase, TyrRS
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Tyrosyl tRNA synthetase/TyrRS protein (His tag N-Terminus) (AB107141)
15% SDS-PAGE showing ab107141 (3 μg) at approximately 61.3 kDa.
反应性数据
产品详情
序列信息
性能和储存信息
形式
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TyrRS plays an important role in ensuring the fidelity of protein translation within cells. It facilitates the correct pairing of tRNA^Tyr with its corresponding tyrosine amino acid contributing to the accuracy of protein production. This enzyme is part of the aminoacyl-tRNA synthetase complex a multi-enzyme complex that catalyzes the attachment of specific amino acids to their appropriate tRNA molecules an important step in the translation process.
Pathways
TyrRS is involved in the protein synthesis pathway where it functions alongside other aminoacyl-tRNA synthetases to help maintain the genetic code's accuracy. Additionally TyrRS is implicated in the aminoacyl-tRNA biosynthesis pathway connecting its activity with enzymes responsible for similar processes. It works closely with related enzymes such as phenylalanyl-tRNA synthetase (PheRS) and tryptophanyl-tRNA synthetase (TrpRS) through these pathways ensuring coordinated protein synthesis.
常规信息
功能
Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction : tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed : 25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed : 25533949). Activity is switched upon resveratrol-binding : resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed : 25533949).
序列相似性
Belongs to the class-I aminoacyl-tRNA synthetase family.
亚细胞定位
Nucleus
靶点信息
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