AB153420

重组人TRPV5蛋白

Name: 重组人TRPV5蛋白 (ab153420)| Abcam中文官网
Brand: Abcam Limited
SKU: AB153420
Price: 6810 CNY
Availability: InStock

Recombinant Human TRPV5 protein

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Recombinant Human TRPV5 protein is a Human Fragment protein, in the 1 to 100 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

ECAC1, TRPV5, Transient receptor potential cation channel subfamily V member 5, TrpV5, Calcium transport protein 2, Epithelial calcium channel 1, Osm-9-like TRP channel 3, CaT2, ECaC, ECaC1, OTRPC3

1 Images

SDS-PAGE - Recombinant Human TRPV5 protein (AB153420)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TRPV5 protein (AB153420)

ab153420 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

应用

ELISA, WB

applications

生物活性

访问

Q9NQA5

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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序列信息

[{"sequence":"MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLME","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":100,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NQA5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TRPV5 also known as ECaC1 is a member of the transient receptor potential (TRP) channel family. This protein functions mechanically as a calcium-selective ion channel playing a role in calcium reabsorption in the kidneys. TRPV5 has a molecular mass of approximately 98 kDa. It is expressed mainly in the epithelial cells of the distal convoluted tubules and connecting tubules of the kidney where it facilitates the passage of calcium ions across cell membranes.

Biological function summary

TRPV5 operates as a critical component in the regulation of calcium homeostasis. It exists as a monomer but often forms functional complexes with other calcium-transporting proteins to fulfill its role. TRPV5 modulates the amount of calcium that is reabsorbed from urine back into the bloodstream a process essential for maintaining proper levels of calcium in the body and supporting various physiological functions including muscle contraction and nerve conduction.

Pathways

TRPV5 plays a significant role in the renal calcium reabsorption pathway. By facilitating the entry of calcium ions into kidney epithelial cells TRPV5 works in conjunction with calbindin-D28K a calcium-binding protein which buffers intracellular calcium levels. Another important pathway involving TRPV5 is vitamin D-mediated regulation of calcium balance where vitamin D enhances the expression of TRPV5 in response to calcium requirements in the body.

Decreased function or expression of TRPV5 can be linked to disorders such as hypercalciuria characterized by excessive urinary calcium excretion and nephrolithiasis commonly known as kidney stones. Mutations or dysregulation in TRPV5 may interact with TRPV6 another TRP channel member which also influences calcium transport in epithelial tissues. Studying TRPV5's involvement in these conditions may provide insights into novel therapeutic strategies for managing calcium-related disorders.

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特殊说明

形式

Liquid

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常规信息

功能

Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed : 11549322, PubMed : 18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed : 11549322, PubMed : 18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).

序列相似性

Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.

翻译后修饰

Glycosylated.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information TRPV5

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重组人TRPV5蛋白

Recombinant Human TRPV5 protein

SDS-PAGE - Recombinant Human TRPV5 protein (AB153420)

关键信息

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液