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AB130027

重组人 Tropomodulin 3 蛋白 (His tag N-Terminus)

Recombinant Human Tropomodulin 3 protein (His tag N-Terminus)

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Recombinant Human Tropomodulin 3 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 352 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

查看别名

Tropomodulin-3, Ubiquitous tropomodulin, U-Tmod, TMOD3

1 Images
SDS-PAGE - Recombinant Human Tropomodulin 3 protein (His tag N-Terminus) (AB130027)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Tropomodulin 3 protein (His tag N-Terminus) (AB130027)

15% SDS-PAGE analysis of 3 μg ab130027.

关键信息

纯度

>80% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q9NYL9

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMALPFRKDLEKYKDLDEDELLGNLSETELKQLETVLDDLDPENALLPAGFRQKNQTSKSTTGPFDREHLLSYLEKEALEHKDREDYVPYTGEKKGKIFIPKQKPVQTFTEEKVSLDPELEEALTSASDTELCDLAAILGMHNLITNTKFCNIMGSSNGVDQEHFSNVVKGEKILPVFDEPPNPTNVEESLKRTKENDAHLVEVNLNNIKNIPIPTLKDFAKALETNTHVKCFSLAATRSNDPVATAFAEMLKVNKTLKSLNVESNFITGVGILALIDALRDNETLAELKIDNQRQQLGTAVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNNDLVRKRRVEGDHQ","proteinLength":"Full Length","predictedMolecularWeight":"42 kDa","actualMolecularWeight":null,"aminoAcidEnd":352,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NYL9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Tropomodulin 3 also known as TMOD3 serves an important role in regulating the dynamics of the actin cytoskeleton. It caps the pointed end of actin filaments which prevents both their elongation and disassembly. TMOD3 has a molecular mass of approximately 40 kDa. This protein is expressed in various tissues including the heart liver and lungs indicating its broad functional significance across multiple systems.
Biological function summary

Tropomodulin 3 interacts with components of the cytoskeleton to help maintain cell shape and stability. It often functions as part of a multi-protein complex with tropomyosin which stabilizes the actin filament and protects it from depolymerization. Through its interaction with actin and tropomyosin TMOD3 influences cell motility division and muscle contraction essential processes in cellular and tissue dynamics.

Pathways

Tropomodulin 3 plays a part in the actin cytoskeleton regulation pathway. It regulates the turnover and length of actin filaments which connect to processes like cell adhesion and movement. The regulation of actin filament dynamics by TMOD3 influences interactions with associated proteins such as myosin which drives cellular movements and mechanical support.

Tropomodulin 3 has been linked to specific pathologies such as cardiomyopathies and certain cancers. In conditions of cardiomyopathy TMOD3 expression or function disturbances can lead to improper cardiac muscle function often involving related proteins like myosin and tropomyosin. Moreover aberrant TMOD3 activity has also been associated with cancer metastasis where altered actin dynamics contribute to increased cell invasiveness and tumor spread.
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特殊说明

形式

Liquid

附加说明

ab130027 was purified using conventional chromatography techniques.

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常规信息

功能

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

序列相似性

Belongs to the tropomodulin family.

亚细胞定位

Cytoskeleton

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产品实验方案

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靶点信息

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
See full target information TMOD3
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搭配使用产品

Proteins & Peptides

AB119162

Recombinant Human Tropomyosin protein

SDS-PAGE - Recombinant Human Tropomyosin protein (AB119162)

  • 0
  • 0
Proteins & Peptides

AB235676

Recombinant Human ENOX1 protein (His tag)

SDS-PAGE - Recombinant Human ENOX1 protein (His tag) (AB235676)

  • 0
  • 0
Primary Antibodies

AB249317

Anti-Tropomodulin 3 antibody [EPR10303(B)] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tropomodulin 3 antibody [EPR10303(B)] - BSA and Azide free (AB249317)

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  • 0
Cell Lines & Lysates

AB265543

Human TMOD3 (Tropomodulin 3) knockout HeLa cell line

Sanger Sequencing - Human TMOD3 (Tropomodulin 3) knockout HeLa cell line (AB265543)

  • 0
  • 0

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