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AB176057

重组人 TRIAP1 蛋白 (His tag N-Terminus)

Recombinant Human TRIAP1 protein (His tag N-Terminus)

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Recombinant Human TRIAP1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 76 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

查看别名

15E1.1, HSPC132, TRIAP1, TP53-regulated inhibitor of apoptosis 1, Protein 15E1.1, WF-1, p53-inducible cell-survival factor, p53CSV

1 Images
SDS-PAGE - Recombinant Human TRIAP1 protein (His tag N-Terminus) (AB176057)
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Supplier Data

SDS-PAGE - Recombinant Human TRIAP1 protein (His tag N-Terminus) (AB176057)

15% SDS-PAGE analysis of ab176057 (3μg).

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

O43715

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMNSVGEACTDMKREYDQCFNRWFAEKFLKGDSSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS","proteinLength":"Full Length","predictedMolecularWeight":"11.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":76,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O43715","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TRIAP1 also known as p53-regulated apoptosis-inducing protein 1 is a small protein with a mass of approximately 10 kDa. This protein is expressed in various tissues particularly those with high proliferative activity. TRIAP1 interacts with key components of cytochrome c release and helps to regulate the mitochondria's response to apoptotic signals. Its mechanical role is essential in cell survival and involves interactions with other proteins to stabilize the mitochondrial outer membrane.
Biological function summary

TRIAP1 is involved in maintaining mitochondrial function and promoting cell survival under stress conditions. It plays a significant role by forming a complex with other mitochondrial proteins such as PRELID1 which is involved in lipid transfer and homeostasis. This protein regulates the release of apoptogenic factors from mitochondria therefore controlling the intrinsic apoptosis pathway. Additionally TRIAP1's activity facilitates the stabilization of mitochondrial membranes against stress-induced depolarization.

Pathways

TRIAP1 plays an important role in the intrinsic apoptosis pathway where it prevents mitochondrial outer membrane permeabilization. It is closely related to the p53 signaling pathway as p53 regulates TRIAP1 expression levels in response to cellular stress. Through this pathway TRIAP1 collaborates with proteins like BCL-2 family members to maintain mitochondrial integrity and prevent apoptosis ensuring cellular homeostasis under stress conditions.

TRIAP1 has been implicated in cancer development where its overexpression correlates with resistance to apoptosis in tumor cells. Its interaction with p53 and BCL-2 family members influences tumor progression and treatment resistance making it relevant in certain cancers like breast and ovarian cancer. Furthermore TRIAP1's involvement in metabolic disorders is observed through its role in maintaining mitochondrial function which can affect conditions such as mitochondrial dysfunction syndromes. Understanding these connections may offer insights into targeted therapeutic interventions.
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特殊说明

形式

Liquid

附加说明

ab176057 is purified using conventional chromatography techniques.

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常规信息

功能

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1 : PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed : 23931759). Likewise, the TRIAP1 : PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed : 26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed : 15735003).

序列相似性

Belongs to the TRIAP1/MDM35 family.

亚细胞定位

Mitochondrion

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产品实验方案

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靶点信息

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1 : PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed : 23931759). Likewise, the TRIAP1 : PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed : 26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed : 15735003).
See full target information TRIAP1
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