重组人 TRFP/MED20 蛋白 (His tag N-Terminus)
Recombinant Human TRFP/MED20 protein (His tag N-Terminus)
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Recombinant Human TRFP/MED20 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 212 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
查看别名
TRFP, MED20, Mediator of RNA polymerase II transcription subunit 20, Mediator complex subunit 20, TRF-proximal protein homolog, hTRFP
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human TRFP/MED20 protein (His tag N-Terminus) (AB139245)
15% SDS-PAGE analysis of 3 µg ab139245.
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The Mediator complex which includes MED20 as one of its subunits plays a significant role in the initiation of transcription. MED20 forms part of the larger Mediator complex working closely with other subunits to modulate gene expression. By serving as a scaffold it helps stabilize interactions between transcription factors and RNA polymerase II enhancing transcription efficiency. The complex influences cell growth differentiation and response to cellular signals.
Pathways
MED20's presence in the Mediator complex situates it in critical transcription regulation pathways such as the RNA polymerase II transcription initiation pathway. It interacts with proteins like CDK8 and CCNC integral in controlling transcription by regulating Mediator's cyclin-dependent kinase activity. MED20 fosters connections between regulatory proteins and RNA polymerase II affecting transcription-related cellular signaling.
特殊说明
形式
Liquid
附加说明
ab139245 is purified using conventional chromatography techniques.
常规信息
功能
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
序列相似性
Belongs to the Mediator complex subunit 20 family.
亚细胞定位
Nucleus
靶点信息
搭配使用产品
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