重组人TRAP/CD40L蛋白(Soluble, Animal Free)
Recombinant human TRAP/CD40L protein (Soluble, Animal Free)
- Bioactive
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Recombinant human TRAP/CD40L protein (Soluble, Animal Free) is a Human Full Length protein, in the 113 to 261 aa range, expressed in Escherichia coli, with >98%, <1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC, FuncS.
查看别名
CD154, CD40L, TNFSF5, TRAP, CD40LG, CD40 ligand, CD40-L, T-cell antigen Gp39, TNF-related activation protein, Tumor necrosis factor ligand superfamily member 5
- FuncS
Unknown
Functional Studies - Recombinant human TRAP/CD40L protein (Soluble, Animal Free) (AB179625)
Functional analysis of ab179625
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human TRAP/CD40L protein (Soluble, Animal Free) (AB179625)
SDS PAGE analysis of ab179625 under non-reducing (-) and reducing (+) conditions. Stained with Coomassie Blue.
反应性数据
产品详情
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The interaction between CD40L and CD40 triggers cell proliferation differentiation and apoptosis in immune cells. CD40L contributes to the formation of an immunological synapse encompassing its role in T helper cell function. Furthermore CD40L is implicated in the activation of B cells which are necessary for antibody class switching and memory cell generation. Its broad influence shows CD40L's involvement in immune system regulation and response.
Pathways
CD40L is integral to the CD40 signaling pathway which is involved in immune and inflammatory responses. CD40L activates the NF-kB and JNK signaling pathways by engaging with CD40 which then drives the transcription of genes related to immune response. This signaling cascade impacts several other proteins such as TRAF proteins which act as intermediaries in propagating the signal.
特殊说明
形式
Lyophilized
附加说明
Also determined by HPCL and spectroscopy at 280 nm.
常规信息
功能
Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed : 1280226, PubMed : 31331973). Costimulates T-cell proliferation and cytokine production (PubMed : 8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed : 8617933). Induces the activation of NF-kappa-B (PubMed : 15067037, PubMed : 31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed : 15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed : 15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).. CD40 ligand, soluble form. Acts as a ligand for integrins, specifically ITGA5 : ITGB1 and ITGAV : ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
序列相似性
Belongs to the tumor necrosis factor family.
翻译后修饰
The soluble form derives from the membrane form by proteolytic processing.. N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.. Not O-glycosylated.
靶点信息
搭配使用产品
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