重组人 TMEM97 蛋白 (GST tag N-Terminus)
Recombinant Human TMEM97 protein (GST tag N-Terminus)
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Recombinant Human TMEM97 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 69 aa range, expressed in Wheat germ, suitable for ELISA, WB.
查看别名
MAC30, S2R, TMEM97, Sigma intracellular receptor 2, Sigma-2 receptor, Sigma2 receptor, Meningioma-associated protein 30, Transmembrane protein 97
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human TMEM97 protein (GST tag N-Terminus) (AB162150)
ab162150 on a 12.5% SDS-PAGE stained with Coomassie Blue.
搭配使用产品
反应性数据
序列信息
性能和储存信息
形式
纯化工艺
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TMEM97 interacts with cholesterol influencing its homeostasis within the cells. It plays a role as a receptor that mediates cholesterol regulation and transport. TMEM97 partners with the low-density lipoprotein receptor (LDLR) family to assist in these functions. It is thought to function in complex with other proteins impacting how cells manage cholesterol levels and their own lipid compositions. This gives TMEM97 a significant position in cellular lipid metabolism.
Pathways
TMEM97 participates in cholesterol biosynthesis and transport pathways. It associates with LXR/RXR signaling which is important for lipid homeostasis and cholesterol metabolism. TMEM97 and its interaction with LDL receptors place it centrally in these pathways influencing how cholesterol is absorbed and processed. TMEM97's involvement suggests a critical role in maintaining lipid balance and supporting healthy cellular functions through these pathways.
常规信息
功能
Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-bound protein trafficking, and receptor stabilization at the cell surface (Probable) (PubMed : 19583955, PubMed : 23922215, PubMed : 25620095, PubMed : 27378690, PubMed : 28559337, PubMed : 30443021, PubMed : 34233061, PubMed : 34799735, PubMed : 35970844). Forms a ternary complex with PGRMC1 receptor and low density lipoprotein receptor/LDLR at the plasma membrane, which increases LDLR-mediated LDL cholesterol internalization (PubMed : 30443021). Decreases lysosomal sterol transporter NPC1 availability to the cell, probably through NPC1-binding, hence controlling lipid transport, including cholesterol and LBPA, outside of late endosome/lysosome (PubMed : 19583955, PubMed : 27378690). Binds regio- and stereoselective ligand 20(S)-hydroxycholesterol (20(S)-OHC) which enhances TMEM97-NPC1 interaction and decreases TMEM97-PGRMC1 and TMEM97-TSPO interactions, thereby linking OHC binding to cholesterol homeostasis (PubMed : 34799735, PubMed : 37047353). Also able to bind cholesterol (By similarity). Binds histatin 1 (Hst 1)/HN1 salivary peptide at the ER membrane, which is critical for increasing mitochondria-ER contacts and stimulating Hst1 wound healing properties (PubMed : 34233061, PubMed : 35970844). May alter the activity of some cytochrome P450 proteins (PubMed : 22292588). Although shows homologies with sterol isomerases (EXPERA domain), not able to catalyze sterol isomerization (Probable) (PubMed : 34880501). However, may act as sensors of these molecules (Probable) (PubMed : 34880501). Acts as a quality control factor in the ER, promoting the proteolytic degradation of nonproductive and extramitochondrial precursor proteins in the ER membrane thus removing them from the ER surface (By similarity).
序列相似性
Belongs to the TMEM97/sigma-2 receptor family.
亚细胞定位
Nucleus membrane
靶点信息
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