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AB165536

重组人TMED6蛋白

Recombinant Human TMED6 protein

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(1 Publication)

Recombinant Human TMED6 protein is a Human Full Length protein, in the 1 to 240 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

UNQ9146/PRO34237, TMED6, Transmembrane emp24 domain-containing protein 6, p24 family protein gamma-5, p24gamma5

1 Images
SDS-PAGE - Recombinant Human TMED6 protein (AB165536)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TMED6 protein (AB165536)

ab165536 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

ELISA, WB

applications

生物活性

No

访问

Q8WW62

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MSPLLFGAGLVVLNLVTSARSQKTEPLSGSGDQPLFRGADRYDFAIMIPPGGTECFWQFAHQTGYFYFSCEVQRTVGMSHDRHVAATAHNPQGFLIDTSQGVRGQINFSTQETGFYQLCLSNQHNHFGSVQVYLNFGVFYEGPETDHKQKERKQLNDTLDAIEDGTQKVQNNIFHMWRYYNFARMRKMADFFLIQSNYNYVNWWSTAQSLVIILSGILQLYFLKRLFNVPTTTDTKKPRC","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":240,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8WW62","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TMED6 also known as Transmembrane Emp24 domain-containing protein 6 plays a role in cellular transport processes. It is a protein with a mass of about 29 kDa. TMED6 is involved in the trafficking of proteins between the endoplasmic reticulum and the Golgi apparatus. Expression of TMED6 is seen in various tissues including liver heart and brain highlighting its broad relevance in different physiological processes.
Biological function summary

TMED6 participates in maintaining the integrity of the secretory pathway. It is part of the p24 family which contributes to the coat protein complex (COPI and COPII) vesicles responsible for shuttling proteins between cellular compartments. This role facilitates the correct sorting and modification of proteins ensuring they reach their intended cellular destinations.

Pathways

TMED6 has an integral part in the secretory pathway and the vesicular transport process. It interacts with proteins like COPI and COPII which are important for vesicle budding from the endoplasmic reticulum. The secretory pathway is essential for protein processing and trafficking affecting how cells respond to various stimuli and maintain homeostasis.

Researchers have investigated TMED6's connection to conditions such as Alzheimer's disease and cardiovascular issues. Alzheimer's disease shows altered endoplasmic reticulum and Golgi function where TMED6's interactions with proteins such as gamma-secretase suggest a potential role in pathogenesis. Additionally cardiovascular disorders involve disruptions in protein transport pathways wherein TMED6's function in vesicular traffic could influence disease states.
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特殊说明

形式

Liquid

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常规信息

序列相似性

Belongs to the EMP24/GP25L family.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

See full target information TMED6
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:1815 PubMed35383192

2022

RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dimitri Van Simaeys,Adriana De La Fuente,Serena Zilio,Alessia Zoso,Victoria Kuznetsova,Oscar Alcazar,Peter Buchwald,Andrea Grilli,Jimmy Caroli,Silvio Bicciato,Paolo Serafini
View all publications
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