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AB275556

重组人Thyroid Peroxidase/TPO蛋白(His tag)

Recombinant Human Thyroid Peroxidase/TPO protein (His tag)

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Recombinant Human Thyroid Peroxidase/TPO protein (His tag) is a Human Fragment protein, in the 7 to 220 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

Thyroid peroxidase, TPO

1 Images
SDS-PAGE - Recombinant Human Thyroid Peroxidase/TPO protein (His tag) (AB275556)
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Supplier Data

SDS-PAGE - Recombinant Human Thyroid Peroxidase/TPO protein (His tag) (AB275556)

SDS-PAGE analysis of ab275556, 15% gel.

关键信息

纯度

>95% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

P07202

不含动物源

No

不含载体蛋白

No

种属

Human

复溶

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

存储溶液

pH: 8 Constituents: PBS, 82.8% Trehalose, 0.17% Sodium-N-Lauroylsarcosinate

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB325996

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands) (AB325996)

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Assay Kits

AB178632

Anti-Thyroid Peroxidase ELISA Kit

Indirect ELISA - Anti-Thyroid Peroxidase ELISA Kit (AB178632)

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Proteins & Peptides

AB152743

Recombinant Human Thyroglobulin protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Thyroglobulin protein (GST tag N-Terminus) (AB152743)

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Proteins & Peptides

AB310793

Recombinant Human IL-24 Protein (His tag)

SDS-PAGE - Recombinant Human IL-24 Protein (His tag) (AB310793)

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Primary Antibodies

AB109383

Anti-Thyroid Peroxidase/TPO antibody [EPR5380]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Peroxidase/TPO antibody [EPR5380] (AB109383)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"LSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVV","proteinLength":"Fragment","predictedMolecularWeight":"25.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":220,"aminoAcidStart":7,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P07202","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Lyophilized
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Thyroid Peroxidase (TPO) also known as thyroperoxidase is an enzyme with a molecular mass of around 105 kDa. It is expressed in the thyroid gland's follicular cells. TPO plays a mechanical role in the synthesis of thyroid hormones by catalyzing iodination and coupling reactions needed to produce triiodothyronine (T3) and thyroxine (T4). These hormones are essential for regulating metabolism growth and development. The activity of TPO is an important step in thyroid hormone production.
Biological function summary

TPO participates in the thyroid's hormone biosynthesis pathway. It forms a part of the multi-enzyme complex that includes thyroglobulin and iodide. The enzyme facilitates the iodination of tyrosine residues on thyroglobulin and the coupling of iodotyrosines important for creating active thyroid hormones. TPO's enzymatic function is important for maintaining appropriate levels of circulating T3 and T4 impacting various physiological processes in the body.

Pathways

TPO contributes to the thyroid hormone synthesis pathway which is a critical pathway for metabolic regulation. It works in close association with other proteins such as thyroglobulin and sodium/iodide symporter (NIS) to ensure efficient thyroid hormone production. TPO's involvement in these pathways indicates its importance in the endocrine system's normal function and homeostasis.

TPO is often associated with autoimmune thyroid diseases like Hashimoto's thyroiditis and Graves' disease. High TPO antibodies such as anti-TPO antibodies are commonly detected in these conditions indicating an autoimmune response against the thyroid. The presence of high anti-thyroid peroxidase antibodies can lead to the destruction of thyroid tissue often resulting in hypothyroidism. TPO's connection to these diseases highlights its role in autoimmune conditions affecting thyroid function.
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常规信息

功能

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

序列相似性

Belongs to the peroxidase family. XPO subfamily.

翻译后修饰

Glycosylated.. Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.. Cleaved in its N-terminal part.

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产品实验方案

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靶点信息

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
See full target information Thyroid peroxidase
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