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AB98233

重组人 THTPA 蛋白 (His tag N-Terminus)

Recombinant Human THTPA protein (His tag N-Terminus)

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Recombinant Human THTPA protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 230 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

查看别名

Thiamine-triphosphatase, ThTPase, THTPA

1 Images
SDS-PAGE - Recombinant Human THTPA protein (His tag N-Terminus) (AB98233)
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SDS-PAGE - Recombinant Human THTPA protein (His tag N-Terminus) (AB98233)

15% SDS-PAGE analysis of 3μg ab98233

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

Mass Spec, SDS-PAGE

applications

生物活性

No

访问

Q9BU02

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAQGLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHWLRRREDSGWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGAGDVAAVLGPLGLQEVASFVTKRSAWKLVLLGADEEEPQLRVDLDTADFGYAVGEVEALVHEEAEVPTALEKIHRLSSMLGVPAQETAPAKLIVYLQRFRPQDYQRLLEVNSSRERPQETEDPDHCLG","proteinLength":"Full Length","predictedMolecularWeight":"27.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":230,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BU02","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The target THTPA also known as thiamine-triphosphatase is an enzyme involved in hydrolyzing thiamine triphosphate (ThTP) to thiamine diphosphate (ThDP). THTPA has a molecular mass of approximately 33 kDa. High expression levels are found in human brain and liver tissues suggesting a role in these organ systems. The enzyme's precise action helps control levels of ThTP a molecule with potential signaling functions in cells.
Biological function summary

THTPA converts thiamine triphosphate to thiamine diphosphate playing an important role in the management of cellular energy processes. THTPA functions independently without being a part of a larger multi-protein complex. The regulation of thiamine phosphate derivatives including ThDP is essential for proper metabolic functions and cellular energy homeostasis.

Pathways

The action of THTPA connects to the thiamine metabolism pathway. This pathway includes interactions with other enzymes like thiamine pyrophosphokinase which assists in the conversion of thiamine to ThDP. Another associated pathway is the biosynthesis of cofactors where thiamine derivatives serve as coenzymes in several enzymatic reactions influencing the activity of proteins such as pyruvate dehydrogenase.

Alterations in THTPA activity are linked to neurological conditions like Wernicke-Korsakoff syndrome and other thiamine deficiency disorders. This connection arises because thiamine is an essential nutrient important for neural function. Reduced THTPA activity may disturb thiamine phosphate levels paired with protein ThDP potentially leading to metabolic distress and contributing to disease development.
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特殊说明

形式

Liquid

附加说明

ab98233 was purified using conventional chromatography techniques.

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常规信息

功能

Hydrolase highly specific for thiamine triphosphate (ThTP).

序列相似性

Belongs to the ThTPase family.

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产品实验方案

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靶点信息

Hydrolase highly specific for thiamine triphosphate (ThTP).
See full target information THTPA
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