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AB181931

重组人 THAP7 蛋白 (denatured) (His tag N-Terminus)

Recombinant Human THAP7 protein (denatured) (His tag N-Terminus)

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Recombinant Human THAP7 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 309 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

THAP domain-containing protein 7, THAP7

1 Images
SDS-PAGE - Recombinant Human THAP7 protein (denatured) (His tag N-Terminus) (AB181931)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human THAP7 protein (denatured) (His tag N-Terminus) (AB181931)

15% SDS-PAGE analysis of 3 μg ab181931.

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q9BT49

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMPRHCSAAGCCTRDTRETRNRGISFHRLPKKDNPRRGLWLANCQRLDPSGQGLWDPASEYIYFCSKHFEEDCFELVGISGYHRLKEGAVPTIFESFSKLRRTTKTKGHSYPPGPAEVSRLRRCRKRCSEGRGPTTPFSPPPPADVTCFPVEEASAPATLPASPAGRLEPGLSSPFSDLLGPLGAQADEAGCSAQPSPERQPSPLEPRPVSPSAYMLRLPPPAGAYIQNEHSYQVGSALLWKRRAEAALDALDKAQRQLQACKRREQRLRLRLTKLQQERAREKRAQADARQTLKEHVQDFAMQLSSSMA","proteinLength":"Full Length","predictedMolecularWeight":"36.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":309,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BT49","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

THAP7 also known as THAP domain-containing protein 7 functions mechanically as a transcriptional repressor. It is a part of the THAP domain protein family which has a conserved zinc finger DNA-binding domain. THAP7 has a molecular mass of approximately 66 kDa. It is expressed in several tissues with notable presence in the heart and testis. The presence of THAP7 in various tissues suggests it may have diverse roles in cellular processes.
Biological function summary

The actions of THAP7 involve regulating gene expression and cell cycle control. It interacts with other proteins to form transcriptional repressor complexes impacting gene silencing. These activities play roles in cell proliferation and differentiation. THAP7's involvement in these fundamental processes indicates its importance in maintaining cellular homeostasis.

Pathways

THAP7 participates in cell cycle regulation and transcription pathways. It has associations with the retinoblastoma pathway collaborating with proteins like E2F transcription factors to influence cell cycle progression. These interactions show that THAP7 contributes to the control of cellular division and proliferation impacting the transition through cell cycle phases.

THAP7 has links to cancer and cardiovascular diseases. Dysregulation of THAP7 expression or function may disrupt normal cell cycle control potentially leading to tumorigenesis. In cardiovascular diseases its expression in cardiac tissues associates with proteins involved in heart function. Understanding THAP7's roles could provide insights into therapeutic targets for these diseases.
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特殊说明

形式

Liquid

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常规信息

功能

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.
See full target information THAP7
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