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AB125542

重组人TESK1蛋白

Recombinant Human TESK1 protein

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Recombinant Human TESK1 protein is a Human Full Length protein, in the 1 to 626 aa range, expressed in Baculovirus infected Sf9 cells, with >70%, suitable for SDS-PAGE, WB.

查看别名

Dual specificity testis-specific protein kinase 1, Testicular protein kinase 1, TESK1

1 Images
SDS-PAGE - Recombinant Human TESK1 protein (AB125542)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human TESK1 protein (AB125542)

SDS-PAGE analysis of ab125542.

关键信息

纯度

>70% Densitometry

表达系统

Baculovirus infected Sf9 cells

标签

Tag free

应用

SDS-PAGE, WB

applications

生物活性

No

访问

Q15569

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"106 kDa","actualMolecularWeight":null,"aminoAcidEnd":626,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q15569","tags":[]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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特殊说明

形式

Liquid

附加说明

Purity was determined to be >70% by densitometry. Affinity purified.

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常规信息

功能

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed : 15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed : 25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).

序列相似性

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

翻译后修饰

Autophosphorylated on serine and tyrosine residues.

亚细胞定位

Cytoskeleton

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产品实验方案

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靶点信息

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed : 15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed : 25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).
See full target information Dual specificity testis-specific protein kinase 1
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