重组人Tankyrase蛋白
Recombinant human Tankyrase protein
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Recombinant human Tankyrase protein is a Human Fragment protein, in the 1001 to 1327 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
查看别名
PARP5A, PARPL, TIN1, TINF1, TNKS1, TNKS, Poly [ADP-ribose] polymerase tankyrase-1, ADP-ribosyltransferase diphtheria toxin-like 5, Poly [ADP-ribose] polymerase 5A, Protein poly-ADP-ribosyltransferase tankyrase-1, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I, Tankyrase-1, ARTD5, TANK1
- FuncS
Supplier Data
Functional Studies - Recombinant human Tankyrase protein (AB198639)
Specific activity of ab198639.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human Tankyrase protein (AB198639)
4-20% SDS-PAGE with Coomassie staining
Lane 1 : 3.8 μg ab198639
Lane 2 : Protein marker
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Tankyrase functions in diverse cellular processes. It participates in telomere maintenance by ADP-ribosylating TRF1 a telomere-binding protein leading to TRF1's disassembly from telomeres. Moreover tankyrase acts in the regulation of Wnt/β-catenin signaling where it associates with components like AXIN influencing the stability of the β-catenin destruction complex. Tankyrase can also be part of larger protein complexes such as the shelterin complex playing a role in safeguarding chromosome ends.
Pathways
Tankyrase integrates into key signaling networks. In the Wnt/β-catenin pathway tankyrase's interaction with AXIN controls the availability of β-catenin an important transcription co-activator in cell proliferation and differentiation. This enzyme also connects with the telomere maintenance pathway engaging TRF1 and contributing to telomere elongation and stability. Through these pathways tankyrase engages in processes vital for cell growth and genome integrity.
特殊说明
形式
Liquid
附加说明
Affinity purified.
常规信息
功能
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed : 10988299, PubMed : 11739745, PubMed : 16076287, PubMed : 19759537, PubMed : 21478859, PubMed : 22864114, PubMed : 23622245, PubMed : 25043379, PubMed : 28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex : poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed : 19759537, PubMed : 21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed : 21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed : 11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed : 22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed : 10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed : 16076287). Stimulates 26S proteasome activity (PubMed : 23622245).
序列相似性
Belongs to the ARTD/PARP family.
翻译后修饰
Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis.. Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation. Deubiquitinated by USP25; leading to stabilization (PubMed:28619731).. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
亚细胞定位
Cytoskeleton
靶点信息
搭配使用产品
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