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AB108128

重组人 SULT2A1/ST2 蛋白 (His tag N-Terminus)

Recombinant Human SULT2A1/ST2 protein (His tag N-Terminus)

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Recombinant Human SULT2A1/ST2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 285 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

HST, STD, SULT2A1, Sulfotransferase 2A1, ST2A1, Bile salt sulfotransferase, Dehydroepiandrosterone sulfotransferase, Hydroxysteroid Sulfotransferase, ST2, SULT2A3, DHEA-ST, DHEA-ST8

1 Images
SDS-PAGE - Recombinant Human SULT2A1/ST2 protein (His tag N-Terminus) (AB108128)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SULT2A1/ST2 protein (His tag N-Terminus) (AB108128)

15% SDS-PAGE analysis of 3µg ab108128.

关键信息

纯度

>95% SDS-PAGE

ab108128 was purified using conventional chromatography.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q06520

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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搭配使用产品

Primary Antibodies

AB194113

Anti-SULT2A1/ST2 antibody [EPR16096]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT2A1/ST2 antibody [EPR16096] (AB194113)

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Proteins & Peptides

AB151361

Recombinant Human FGF12 protein

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Proteins & Peptides

AB307475

Recombinant Human CD86 protein (Fc Chimera)

Mass Spectrometry - Recombinant Human CD86 protein (Fc Chimera) (AB307475)

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Proteins & Peptides

AB134607

Recombinant Human C1orf33 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human C1orf33 protein (His tag N-Terminus) (AB134607)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

This product was previously labelled as SULT2A1
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE","proteinLength":"Full Length","predictedMolecularWeight":"35.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":285,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q06520","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SULT2A1 also known as ST2 is an enzyme belonging to the sulfotransferase family. It mechanically transfers sulfate groups to hydroxy steroids which include substances like dehydroepiandrosterone (DHEA) as well as other sterols. SULT2A1 exhibits an approximate molecular mass of 34 kDa. Expression occurs mainly in the liver and adrenal glands where it plays important role in steroid metabolism. It is also found in the intestine and skin although at lower levels. This enzyme's function in these tissues suggests its involvement in the local regulation of hormone action and metabolism.
Biological function summary

The role of SULT2A1 extends to the regulation of hormones by sulfurylation which makes compounds more soluble and ready for excretion. This process effectively deactivates certain steroid hormones thereby modulating their activity within the body. SULT2A1 does not typically form part of a larger complex but works independently in modifying steroid substrates. The enzyme's activity allows for regulation of hormone availability and subsequently holds substantial influence over multiple physiological processes.

Pathways

SULT2A1 is active in the steroid metabolism and catabolic pathways. It functions alongside other enzymes like CYP3A4 a cytochrome P450 enzyme to transform and clear hormone derivatives from the body. This cooperation is important for maintaining hormonal balance by converting active hormones into less active forms or preparing them for elimination. SULT2A1 contributes specifically to the homeostasis of androgen and estrogen metabolism through the sulfate conjugation pathway regulating the sensitivity of tissues to these hormones.

Alterations in SULT2A1 activity have connections with adrenal diseases and certain forms of cancer. Overactive or deficient SULT2A1 enzyme function can disrupt hormone levels affecting conditions like congenital adrenal hyperplasia. This condition involves hormone imbalances due to enzyme irregularities upstream where SULT2A1's role in sulfate conjugation remains integral. It is also associated with breast cancer where enzyme interactions with estrogen derivatives might modulate proliferative signals; related proteins include estrogen receptor pathways that influence tumor growth. Understanding SULT2A1's function in these contexts aids in grasping the broader impact of hormone regulation and metabolism in disease development.
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常规信息

功能

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed : 14573603, PubMed : 18042734, PubMed : 19589875, PubMed : 20102295, PubMed : 21187059, PubMed : 2268288, PubMed : 29671343, PubMed : 7678732, PubMed : 7854148). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed : 14573603, PubMed : 18042734, PubMed : 19589875, PubMed : 20102295, PubMed : 21187059, PubMed : 2268288, PubMed : 29671343, PubMed : 7678732, PubMed : 7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed : 14573603, PubMed : 19589875, PubMed : 21187059). Plays a key role in bile acid metabolism, mediating formation of 3-sulfated bile acids (PubMed : 2268288, PubMed : 20102295). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).

序列相似性

Belongs to the sulfotransferase 1 family.

翻译后修饰

The N-terminus is blocked.

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产品实验方案

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靶点信息

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed : 14573603, PubMed : 18042734, PubMed : 19589875, PubMed : 20102295, PubMed : 21187059, PubMed : 2268288, PubMed : 29671343, PubMed : 7678732, PubMed : 7854148). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed : 14573603, PubMed : 18042734, PubMed : 19589875, PubMed : 20102295, PubMed : 21187059, PubMed : 2268288, PubMed : 29671343, PubMed : 7678732, PubMed : 7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed : 14573603, PubMed : 19589875, PubMed : 21187059). Plays a key role in bile acid metabolism, mediating formation of 3-sulfated bile acids (PubMed : 2268288, PubMed : 20102295). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).
See full target information SULT2A1
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